Etiology of the Acrodermatitis Chronica Atrophicans Lesion in Lyme Disease

Spirochete diversity in acrodermatitis chronica atrophicans lesions in a closely defined central European site was compared to that in the local vector population, in human erythema migrans lesions, and in cerebrospinal fluid by amplifying and sequencing a segment of the gene of outer surface protei...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-08, Vol.174 (2), p.421-423
Main Authors: Ohlenbusch, Andreas, Matuschka, Franz-Rainer, Richter, Dania, Christen, Hans-Jürgen, Thomssen, Reiner, Spielman, Andrew, Eiffert, Helmut
Format: Article
Language:English
Subjects:
Acrodermatitis - epidemiology
Acrodermatitis - etiology
Acrodermatitis - microbiology
Animals
Antigens, Surface - genetics
Bacterial diseases
Bacterial diseases of the skin
Bacterial Outer Membrane Proteins - genetics
Bacterial Vaccines
Biological and medical sciences
Borrelia
Borrelia - classification
Borrelia - genetics
Borrelia - isolation & purification
Borrelia afzelii
Borrelia burgdorferi
Borrelia burgdorferi Group
Borrelia garinii
Borrelia Infections - complications
Borrelia Infections - epidemiology
Borrelia Infections - microbiology
Cerebrospinal fluid
Concise Communications
Erythema multiforme
Etiology
Germany - epidemiology
Human bacterial diseases
Humans
Infectious diseases
Lesions
Lipoproteins
Lyme disease
Lyme Disease - complications
Lyme Disease - epidemiology
Lyme Disease - microbiology
Medical sciences
Polymerase Chain Reaction
Sequence Analysis, DNA
Spirochaetales
Ticks - microbiology
Tissue samples
Citations: Items that cite this one
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Description
Summary:Spirochete diversity in acrodermatitis chronica atrophicans lesions in a closely defined central European site was compared to that in the local vector population, in human erythema migrans lesions, and in cerebrospinal fluid by amplifying and sequencing a segment of the gene of outer surface protein A directly from sampled tissues. Borrelia garinii, Borrelia afzelii, and Borrelia burgdorferi acutely infect human skin and invade internal tissues. Only B. afzelii, however, is associated with acrodermatitis chronica atrophicans lesions, persisting chronically where the skin has atrophied.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/174.2.421