Effect of gonadal steroids on bone and other physiological parameters of male broiler chickens

Comparative studies of the effects of estradiol, progesterone, testosterone, cholesterol, and megestrol on juvenile chickens were carried out to determine their effects on bone and other physiological parameters. The chickens were implanted at 6 wk of age with ethylene-vinyl acetate copolymers conta...

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Bibliographic Details
Published in:Poultry science 1996-04, Vol.75 (4), p.556-562
Main Authors: Rath, N C, Huff, W E, Balog, J M, Bayyari, G R
Format: Article
Language:English
Subjects:
acid phosphatase
Acid Phosphatase - analysis
Aging - metabolism
Aging - physiology
alkaline phosphatase
Alkaline Phosphatase - analysis
Animals
anticonceptivos
ashes
Biomechanical Phenomena
blood composition
body parts
Body Weight - drug effects
Body Weight - physiology
Bone and Bones - drug effects
Bone and Bones - metabolism
Bone and Bones - physiology
bone diseases
bone formation
bones
broiler chickens
calcio
calcium
Calcium - blood
cendre
ceniza
Chickens - growth & development
Chickens - metabolism
Chickens - physiology
chicks
cholesterol
Cholesterol - administration & dosage
Cholesterol - blood
Cholesterol - pharmacology
cocks
colesterol
composicion de la sangre
composition du sang
contraceptif
contraceptives
controlled release
coq
Dose-Response Relationship, Drug
Drug Implants
enfermedades oseas
esteroides
Estradiol - administration & dosage
Estradiol - pharmacology
estrogenos
formacion osea
formation des os
fosfatasa acida
fosfatasa alcalina
fosforo
gallos
Gonadal Steroid Hormones - administration & dosage
Gonadal Steroid Hormones - pharmacology
Growth Plate - drug effects
Growth Plate - enzymology
huesos
huesos de los miembros
Iron - blood
liberacion controlada
liberation controlee
limb bones
Liver - drug effects
Liver - growth & development
Liver - physiology
Male
Megestrol - administration & dosage
Megestrol - pharmacology
oestrogene
oestrogens
Organ Size
os des membres
osteopathie
partes del cuerpo
partie du corps
peso
phosphatase acide
phosphatase alcaline
phosphore
phosphorus
Phosphorus - blood
poids
pollito
pollo de engorde
poulet de chair
poussin
progesterona
progesterone
Progesterone - administration & dosage
Progesterone - pharmacology
Progesterone Congeners - pharmacology
resistance mecanique
resistencia mecanica
Space life sciences
steroide
steroids
strength
Testis - drug effects
Testis - growth & development
Testis - physiology
testosteronas
testosterone
Testosterone - administration & dosage
Testosterone - blood
Testosterone - pharmacology
weight
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Summary:Comparative studies of the effects of estradiol, progesterone, testosterone, cholesterol, and megestrol on juvenile chickens were carried out to determine their effects on bone and other physiological parameters. The chickens were implanted at 6 wk of age with ethylene-vinyl acetate copolymers containing steroids equivalent to a weekly dose of 10 mg/kg body weight for 3 consecutive wk. Estradiol caused a gain in body weight and relative liver weight but suppressed the growth of comb and testis. It also increased several serum variables, including triglycerides, cholesterol, calcium, phosphorus, and iron, and reduced testosterone levels. Testosterone produced an increase in comb weight and decreased both testicular and bursar weights. Growths of testis and comb were suppressed in progesterone-implanted chickens, as was the level of serum testosterone. Megestrol stimulated liver growth and increased serum testosterone levels. The lengths, relative weights, diaphyseal diameters, and ash percentages of both femur and tibia did not change significantly due to any treatment except that estradiol reduced tibial weight. Both progesterone and megestrol increased fibular growth plate alkaline and tartarate-resistant acid phosphatase activities. Other steroids did not affect these or the levels of calcium and of phosphorus of the fibular growth plate. Only testosterone caused a marked increase in the breaking strengths of both femur and tibia in all three parameters, i.e., load at yield, Young's modulus, and stress at yield responses. These findings suggest that the effects of steroids on bone in juvenile chickens may be limited.
ISSN:0032-5791
1525-3171
DOI:10.3382/ps.0750556