Levels of steroid and protein hormones in antral fluids of women treated with different combinations of gonadotropins, clomiphene citrate, and a gonadotropin-releasing hormone analog

Levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone (P), and total protein in follicular fluids collected from 18 patients pretreated with a gonadotropin-releasing hormone analog (GnRHa), in association with human menopausal gonadotropin (hMG) and FSH, wer...

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Bibliographic Details
Published in:Fertility and sterility 1988-02, Vol.49 (2), p.249-257
Main Authors: Stone, Bronte A., Vargyas, Joyce M., Marrs, Richard P., Quinn, Patrick J., Batzofin, Joel H., Tan, Tih, Kerin, John F.P., Serafini, Paulo C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Birth control
Body Fluids - metabolism
Clomiphene - therapeutic use
Estradiol - metabolism
Female
Fertilization in Vitro
Follicle Stimulating Hormone - metabolism
Gonadotropin-Releasing Hormone - analogs & derivatives
Gonadotropin-Releasing Hormone - therapeutic use
Gonadotropins, Pituitary - therapeutic use
Gynecology. Andrology. Obstetrics
Hormones - therapeutic use
Humans
Leuprolide
Luteinizing Hormone - metabolism
Medical sciences
Ovarian Follicle - metabolism
Ovarian Follicle - physiology
Progesterone - metabolism
Sterility. Assisted procreation
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Summary:Levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, progesterone (P), and total protein in follicular fluids collected from 18 patients pretreated with a gonadotropin-releasing hormone analog (GnRHa), in association with human menopausal gonadotropin (hMG) and FSH, were compared with values for 69 patients treated with FSH, hMG, FSH/hMG, or clomiphene citrate (CC)/hMG in an in vitro fertilization (IVF) program. The authors have established a number of significant differences in chemical and physical properties of follicular fluids of patients treated by different regimen, and concur with earlier evidence that the volume of a follicle, and its P and total protein content, are related to the maturity of the oocyte nested within the follicle. Overall, however, differences in concentrations of gonadotropins in follicular fluids between groups were not consistent with differences in follicular fluid steroid levels, and levels of immunoactive gonadotropins in follicular fluids were not in accord with dosages of exogenous immunoactive gonadotropin administered during hyperstimulation. The most favorable outcomes of IVF (>70% of oocytes fertilized) were established with oocytes collected from patients treated with FSH only or with CC/hMG, and patients treated with FSH only yielded the highest average number of oocytes which fertilized in vitro (6.2 per patient).
ISSN:0015-0282
1556-5653
DOI:10.1016/S0015-0282(16)59711-8