Comparison of Tc-99m HIG and Ga-67 citrate in the evaluation of bacterial abscess in a rat model

Tc-99m labeled polyclonal human immunoglobulin (HIG) has been shown to be able to localize an inflammatory site. There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes a...

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Bibliographic Details
Published in:Annals of nuclear medicine 1996-02, Vol.10 (1), p.79-83
Main Authors: Güngör, F, Karayalçin, B, Gültekin, M, Paksoy, N, Sentürk, U K, Kaputlu, I, Yildiz, A, Erkiliç, M
Format: Article
Language:English
Subjects:
Abscess - diagnostic imaging
Animals
Citrates
Citric Acid
Disease Models, Animal
Escherichia coli Infections - diagnostic imaging
Evaluation Studies as Topic
Gallium Radioisotopes
Humans
Immunoglobulins
Radionuclide Imaging
Rats
Rats, Wistar
Staphylococcal Infections - diagnostic imaging
Technetium
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Summary:Tc-99m labeled polyclonal human immunoglobulin (HIG) has been shown to be able to localize an inflammatory site. There are several possible explanations for HIG accumulation at focal infection sites such as increased vascular permeability, binding of the Fc part of Ig to Fc receptors of leucocytes and binding directly to bacteria. In this study, we compared Tc-99m HIG and Ga-67 citrate scintigraphy in localizing acute bacterial abscesses induced by E. coli and S. aureus. Serial scintigrams were performed at 1, 4, 24 hr after injection. Tc-99m HIG showed greater accumulation at all times with both infections agents than Ga-67 citrate (p < 0.05). While Tc-99m HIG showed greater accumulation in S. aureus than E. coli (p < 0.05), there was no statistically significant difference between E. coli and S. aureus (p > 0.05) by Ga-67 citrate. Our study suggests that Tc-99m HIG is a superior agent to Ga-67 and bacterial affinity can be a factor responsible for HIG accumulation at focal sites of inflammation.
ISSN:0914-7187
1864-6433
DOI:10.1007/bf03165057