Visible and non-visible endometriosis at laparoscopy in fertile and infertile women and in patients with chronic pelvic pain: a prospective study

In 100 consecutive patients who were undergoing laparoscopy for infertility (group 1, n = 52), chronic pelvic pain (group 2, n = 18) or tubal sterilization (group 3, n = 30, asymptomatic fertile women), peritoneal biopsies were taken from areas of visually normal peritoneum of uterosacral ligaments....

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Bibliographic Details
Published in:Human reproduction (Oxford) 1996-02, Vol.11 (2), p.387-391
Main Authors: Balasch, Juan, Creus, Montserrat, Fabregues, Francisco, Carmona, Francisco, Ordi, Jaime, Martinez-Román, Sergio, Vanrell, Juan A.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsy
Chronic Disease
Contraceptives, Oral
endometriosis
Endometriosis - pathology
Female
Female genital diseases
fertile women
Gynecology. Andrology. Obstetrics
Humans
infertility
Infertility, Female - pathology
Laparoscopy
Medical sciences
Non tumoral diseases
oral contraceptive use
pelvic pain
Pelvic Pain - pathology
Prospective Studies
Reference Values
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Summary:In 100 consecutive patients who were undergoing laparoscopy for infertility (group 1, n = 52), chronic pelvic pain (group 2, n = 18) or tubal sterilization (group 3, n = 30, asymptomatic fertile women), peritoneal biopsies were taken from areas of visually normal peritoneum of uterosacral ligaments. Twenty-six patients in group 1 (50%), eight patients in group 2 (44.4%) and 13 patients in group 3 (43.3%), were found to have laparoscopic evidence of endometriosis elsewhere in the pelvis. The majority of women (80.7% in group 1, 87.5% in group 2, and 100% in group 3) had stage I disease. The incidence of the distinctive appearances of the lesions was similar in the three groups of patients and 7% of all women or 15% (7/47) of those patients having endometriosis at laparoscopy had only subtle (non-‘typical’) endometriotic peritoneal lesions. Uterosacral biopsies showed the presence of endometriotic tissue in three cases (5.7%), two cases (11%) and three cases (10%) in groups 1, 2, and 3 respectively. One of the two patients in group 2 and two of the three patients in group 3 had no evidence of endometriosis at laparoscopy; thus histological study revealed the presence of endometriosis in normal peritoneum hi 11 % (5/47) of patients having macroscopic endometriosis and hi 6% (3/53) of patients without endometriosis at laparoscopy. Previous oral contraceptive users were significantly higher among women having macroscopic and/or microscopic endometriosis than among women without the condition. In conclusion, our prospective study shows a high prevalence (45–50%) of endometriosis (including microscopic forms) in both patients with chronic pelvic pain and asymptomatic women (fertile and infertile), thus supporting the modern concept that in many women endometriosis may be a paraphysiological condition while probably only hi some patients small amounts of endometriosis are an ‘annoyance’ with implications to their reproductive health and may produce symptoms (eg. pelvic pain) and therefore should be defined as a ‘dis-ease’. Previous use of oral contraceptives may increase the risk of developing endometriosis.
ISSN:0268-1161
1460-2350
DOI:10.1093/HUMREP/11.2.387