Acetogenins from annonaceae, inhibitors of mitochondrial complex I

One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of...

Full description

Bibliographic Details

Published in:	Phytochemistry 1996-05, Vol.42 (2), p.253-271
Main Authors:	Zafra-Polo, M.Carmen, González, M.Carmen, Estornell, Ernesto, Sahpaz, Sevser, Cortes, Diego
Format:	Article
Language:	eng
Subjects:	Biological and medical sciences Biotechnology Cell structures and functions Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Furans - chemistry Furans - isolation & purification Furans - pharmacology Metabolism Mitochondria - enzymology Mitochondria and cell respiration Molecular and cellular biology Molecular Structure NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors Photosynthesis, respiration. Anabolism, catabolism Plant physiology and development Plants Plants, Medicinal Species Specificity
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!