The Renin–Angiotensin–Aldosterone System During Haemodialysis With Acetate or Bicarbonate at Different Dialysate Sodium Concentrations

The hormones of the renin–angiotensin–aldosterone system were measured during regular haemodialysis with acetate or bicarbonate at dialysate sodium concentrations of 135, 140, 145, and 150 mmol/l. Plasma renin activity and aldosterone concentration were higher during acetate haemodialysis than durin...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 1987, Vol.2 (6), p.531-536
Main Authors: Krämer, B. K., Ress, K. M., Ulshöfer, T. M., Risler, T.
Format: Article
Language:English
Subjects:
Acetate
Acetates
Adult
Aldosterone - blood
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Angiotensin II - blood
Bicarbonate
Bicarbonates
Biological and medical sciences
Emergency and intensive care: renal failure. Dialysis management
Female
Haemodialysis
High-low sodium dialysis
Humans
Intensive care medicine
Kidney Failure, Chronic - physiopathology
Kidney Failure, Chronic - therapy
Male
Medical sciences
Renal Dialysis
Renin-Angiotensin System
Renin–angiotensin–aldosterone system
Sodium
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Summary:The hormones of the renin–angiotensin–aldosterone system were measured during regular haemodialysis with acetate or bicarbonate at dialysate sodium concentrations of 135, 140, 145, and 150 mmol/l. Plasma renin activity and aldosterone concentration were higher during acetate haemodialysis than during bicarbonate haemodialysis. At lower dialysate sodium concentrations, plasma renin activity (acetate dialysis and bicarbonate dialysis) and aldosterone concentration (only acetate dialysis) were higher than they were at higher dialysate sodium concentrations. Plasma renin activity increased during acetate dialysis, but did not change during bicarbonate dialysis. Aldosterone and potassium concentrations were positively correlated. Aldosterone decreased during haemodialysis (increase to predialysis values at the end of haemodialysis (4 h) at lower dialysate sodium concentrations). It is concluded that the renin-angiotensin-aldosterone system is activated more during acetate dialysis than during bicarbonate dialysis. Aldosterone concentrations seem to be related more closely to serum potassium than to renin–angiotensin–aldosterone system and to serum sodium intradialytically.
ISSN:0931-0509
1460-2385
1460-2385
DOI:10.1093/oxfordjournals.ndt.a091595