Urinary excretion of pyridinium cross-links of collagen in infancy

This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infan...

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Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 1996-04, Vol.45 (4), p.510-514
Main Authors: Tsukahara, Hirokazu, Miura, Masakazu, Hori, Chikahide, Hiraoka, Masahiro, Nosaka, Kazuhiko, Hata, Keishi, Konishi, Yukuo, Sudo, Masakatsu
Format: Article
Language:English
Subjects:
Amino Acids - urine
beta 2-Microglobulin - urine
Biological and medical sciences
Chromatography, High Pressure Liquid
Collagen - metabolism
Collagen - urine
Cross-Sectional Studies
Female
Fluorometry
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Osteoarticular system. Muscles
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phenazopyridine - metabolism
Phenazopyridine - urine
Radioimmunoassay
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Summary:This cross-sectional study evaluated urinary excretion of pyridinium cross-links of collagen, specific markers of ongoing bone resorption, in infants aged 1 week to 7 months and examined the relationship between urinary cross-links and individual renal function. Spot urines from a total of 100 infants were analyzed. The collagen cross-links, pyridinoline (Pyd) and deoxypyridinoline (D-Pyd), were assayed by fluorescence detection after high-performance liquid chromatography (HPLC). β 2-Microglobulin (β 2M), an index of renal tubular function, was determined by radioimmunoassay. In healthy term infants, urinary collagen cross-links were several times higher than the reported data for older children, with peak values seen at 1 month of age. Excretion of Pyd and D-Pyd was also markedly elevated in 1-month-old preterm infants, despite poor somatic growth. Such high excretion of collagen cross-links probably reflects the state of accelerated bone turnover in infancy. The postnatal change in the cross-links was different from that in urinary β 2M, and the values obtained did not correlate with β 2M in either term or preterm infants. These results indicate that cross-link excretion is not influenced directly by individual renal function.
ISSN:0026-0495
1532-8600
DOI:10.1016/S0026-0495(96)90228-0