Invasive Pneumococcal Infections in Human Immunodeficiency Virus-Infected Children

Invasive pneumococcal infection (IPI) is the most common serious bacterial infection in human immunodeficiency virus (HIV)-infected children. Data from a population-based pediatric HIV surveillance project were used to determine the incidence of IPI in HIV-infected children and to conduct a case-con...

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Bibliographic Details
Published in:The Journal of infectious diseases 1996-04, Vol.173 (4), p.870-876
Main Authors: Mao, Charlotte, Harper, Marvin, McIntosh, Kenneth, Reddington, Catherine, Cohen, Joyce, Bachur, Richard, Caldwell, Blake, Hsu, Ho Wen
Format: Article
Language:English
Subjects:
Age Factors
AIDS
AIDS/HIV
Bacteremia
Biological and medical sciences
Child
Child health services
Child, Preschool
Continental Population Groups
Epidemiology
Female
HIV
HIV Infections - complications
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Major Articles
Male
Massachusetts
Medical sciences
Pediatrics
Physiological immunosuppression
Pneumococcal infections
Pneumococcal Infections - epidemiology
Retrospective Studies
Risk Factors
Streptococcus pneumoniae
Vaccination
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Summary:Invasive pneumococcal infection (IPI) is the most common serious bacterial infection in human immunodeficiency virus (HIV)-infected children. Data from a population-based pediatric HIV surveillance project were used to determine the incidence of IPI in HIV-infected children and to conduct a case-control study assessing potential risk factors for IPI in HIV-infected children. There were 50 episodes of IPI and a cumulative incidence of 6.1 cases/100 patient-years through age 7 years. Children with IPI were more likely to have a prior AIDS diagnosis (odds ratio, 4.2; 95% confidence interval, 1.2–15.1) and higher levels of IgG and IgM (P = .01) than were controls. In a separate case-control study, the manifestations of IPI in HIV-infected children were compared with those in HIV-negative controls. Focal complication rates in the 2 groups did not differ; however, HIV-infected children were less likely than controls to have leukocytosis (P < .001) and more likely to have isolates with penicillin resistance (P = .03).
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/173.4.870