WHOLE BLOOD SEROTONIN IN AUTISTIC AND NORMAL SUBJECTS

Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentration (mean ± SE) were significantly higher in drug‐free (N= 21) autistics (205 ± 16 ng/ml) that in normal (136 ± 5.4 ng/ml) The Gaussian distribution of serotonin leve...

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Bibliographic Details
Published in:Journal of child psychology and psychiatry 1987-11, Vol.28 (6), p.885-900
Main Authors: Anderson, George M., Freedman, Daniel X., Cohen, Donald J., Volkmar, Fred R., Hoder, E. Lawrence, McPhedran, Peter, Minderaa, Ruud B., Hansen, Carl R., Young, J. Gerald
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants - therapeutic use
autism
Autistic Disorder - blood
Autistic Disorder - drug therapy
Biological and medical sciences
Blood Platelets - metabolism
Child
Child, Preschool
Chromatography, High Pressure Liquid
Female
Haloperidol - therapeutic use
Humans
Infant
Male
Medical sciences
Miscellaneous
platelet
Platelet Count - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin
Serotonin - blood
Sex Factors
Techniques and methods
Thioridazine - therapeutic use
Tryptophan - blood
typtophan
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Summary:Whole blood serotonin and tryptophan were measured in 87 normal subjects and in 40 autistic subjects. Whole blood serotonin concentration (mean ± SE) were significantly higher in drug‐free (N= 21) autistics (205 ± 16 ng/ml) that in normal (136 ± 5.4 ng/ml) The Gaussian distribution of serotonin level of the unmidicated autistic group suggests the elevation was not due to a subgroup of autistic subject Autistics medicated with medicated with anticonvulsants or neuroleptics had significantly lower serortonin levels than did drug‐free autistic subjects Whole blood trytophan levels and platelet counts were similar in the autistic and normal groups. The possible cause of the hyerserotonemia of autism are discussed
ISSN:0021-9630
1469-7610
DOI:10.1111/j.1469-7610.1987.tb00677.x