The effects of IL12 on B-cell subset function

It has been established by many groups of investigators that interleukin(IL)12 plays a pivotal role in controlling cell-mediated immunity. Accumulating evidence now indicates that IL12 also strongly regulates B-lymphocyte function. It has been generally believed that IL12 does not interact directly...

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Bibliographic Details
Published in:Research in immunology (Paris) 1995-09, Vol.146 (7), p.499-505
Main Authors: Metzger, D.W., Vogel, L.A., Van Cleave, V.H., Lester, T.L., Buchanan, J.M.
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - drug effects
B-Lymphocyte Subsets - drug effects
B-Lymphocyte Subsets - immunology
Humans
Interleukin-12 - pharmacology
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Summary:It has been established by many groups of investigators that interleukin(IL)12 plays a pivotal role in controlling cell-mediated immunity. Accumulating evidence now indicates that IL12 also strongly regulates B-lymphocyte function. It has been generally believed that IL12 does not interact directly with B cells, but mediates it effects on antibody production by stimulating Th1 cells to secrete IFN gamma . IFN gamma is known to enhance production of the Th1-associated isotype, IgG2a, and to inhibit expression of Th2-associated isotypes such as IgG1 and IgE. Thus, it is predicted that IL12 would have similar effects on humoral immunity. In this paper, we review our recent work which shows that IL12 leads to long-term enhancement of conventional antibody response.
ISSN:0923-2494
DOI:10.1016/0923-2494(96)83023-9