Transient diabetes insipidus in pregnancy : a consequence of enhanced placental clearance of arginine vasopressin

We report a patient who presented with transient diabetes insipidus in pregnancy on a background of previous postoperative diabetes insipidus following surgical excision of a prolactinoma. The patient illustrates how the complex changes in water homeostasis occurring during normal pregnancy may unma...

Full description

Saved in:
Bibliographic Details
Published in:Human reproduction (Oxford) 1995-12, Vol.10 (12), p.3322-3324
Main Authors: SOULE, S. G, MONSON, J. P, JACOBS, H. S
Format: Article
Language:English
Subjects:
Adult
Arginine Vasopressin - metabolism
Biological and medical sciences
Body Water - metabolism
Diabetes Insipidus - complications
Diabetes Insipidus - metabolism
Diseases of mother, fetus and pregnancy
Female
Gynecology. Andrology. Obstetrics
Homeostasis
Humans
Medical sciences
Pituitary Neoplasms - complications
Pituitary Neoplasms - surgery
Placenta - metabolism
Pregnancy
Pregnancy in Diabetics - etiology
Pregnancy in Diabetics - metabolism
Pregnancy. Fetus. Placenta
Prolactinoma - complications
Prolactinoma - surgery
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report a patient who presented with transient diabetes insipidus in pregnancy on a background of previous postoperative diabetes insipidus following surgical excision of a prolactinoma. The patient illustrates how the complex changes in water homeostasis occurring during normal pregnancy may unmask latent diabetes insipidus. The major factors operating appear to be a physiological reduction in the thresholds for thirst and arginine vasopressin secretion coupled with a substantial increase in placental clearance of arginine vasopressin. Reversal of these changes after delivery results in normalization of the disordered water homeostasis, with consequent resolution of the diabetes insipidus.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a135912