Proton magnetic resonance spectroscopy of the left medial temporal and frontal lobes in chronic schizophrenia: preliminary report

Proton magnetic resonance spectroscopy (MRS) was performed in 30 medicated schizophrenic patients and 30 normal subjects. Two groups, each containing 15 schizophrenic patients and 15 age- and sex-matched normal subjects, received MRS examinations for different volumes of interest, either the frontal...

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Published in:Psychiatry research 1995-11, Vol.61 (4), p.193-200
Main Authors: Fukuzako, Hiroshi, Takeuchia, Kouzou, Hokazono, Yoshiro, Fukuzako, Tsuyoshi, Yamada, Kouichiro, Hashiguchi, Tomo, Obo, Yoshihiko, Ueyama, Kenichi, Takigawa, Morikuni, Fujimoto, Toshiro
Format: Article
Language:English
Subjects:
Adult
Arousal - physiology
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Choline - metabolism
Creatine - metabolism
Dominance, Cerebral - physiology
Energy Metabolism - physiology
Female
Frontal lobe
Frontal Lobe - physiopathology
Humans
Magnetic Resonance Spectroscopy
Male
Middle Aged
N-Acetylaspartate
Neurocognitive Disorders - diagnosis
Neurocognitive Disorders - physiopathology
Neurocognitive Disorders - psychology
Phosphocreatine - metabolism
Psychiatric Status Rating Scales
Reference Values
Schizophrenia - diagnosis
Schizophrenia - physiopathology
Schizophrenic Psychology
Temporal Lobe - physiopathology
Temporal lobe, medial
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Summary:Proton magnetic resonance spectroscopy (MRS) was performed in 30 medicated schizophrenic patients and 30 normal subjects. Two groups, each containing 15 schizophrenic patients and 15 age- and sex-matched normal subjects, received MRS examinations for different volumes of interest, either the frontal lobe or the medial temporal lobe. Schizophrenic patients showed a decrease in the ratios of N-acetylaspartate (NAA)/choline-containing compounds (Cho) and NAA/creatine-phosphocreatine (Cr). The patients also showed an increase in the ratio of Cho/Cr in the left medial temporal lobe but not in the left frontal lobe. The age at onset of illness correlated positively with the ratios of NAA/Cho and NAA/Cr in the medial temporal lobe. No significant correlation was observed between the ratios of AA/Cho, NAA/Cr, or Cho/Cr in the left medial temporal and frontal lobes and clinical symptomatology as assessed by the Scale for the Assessment of Negative Symptoms and the Positive and Negative Syndrome Scale.
ISSN:0925-4927
0165-1781
1872-7506
1872-7123
DOI:10.1016/0925-4927(95)02622-5