Effects of nitric oxide synthase inhibition on regional hemodynamics and oxygen transport in endotoxic dogs

Nitric oxide synthase (NOS) inhibition has been used to increase blood pressure in humans with septic shock despite a lack of data regarding its effects on O2 delivery (QO2). We studied the effects of NG-nitro-L-arginine methyl ester (L-NAME) on systemic, gut, and hindlimb circulations of endotoxic...

Full description

Saved in:
Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 1995-12, Vol.4 (6), p.415-420
Main Authors: Walker, T A, Curtis, S E, King-VanVlack, C E, Chapler, C K, Vallet, B, Cain, S M
Format: Article
Language:English
Subjects:
Animals
Arginine - analogs & derivatives
Arginine - pharmacology
Dogs
Enzyme Inhibitors - pharmacology
Female
Hemodynamics
Hindlimb - blood supply
Intestines - blood supply
Intestines - enzymology
Lipopolysaccharides
Male
Muscle, Skeletal - blood supply
Muscle, Skeletal - enzymology
NG-Nitroarginine Methyl Ester
Nitric Oxide Synthase - antagonists & inhibitors
Oxygen - physiology
Sepsis - enzymology
Sepsis - physiopathology
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nitric oxide synthase (NOS) inhibition has been used to increase blood pressure in humans with septic shock despite a lack of data regarding its effects on O2 delivery (QO2). We studied the effects of NG-nitro-L-arginine methyl ester (L-NAME) on systemic, gut, and hindlimb circulations of endotoxic dogs. Twelve dogs were infused with 2 mg/kg of LPS over 1 h followed by 60 mL/kg of 6% dextran over 2 h. Six dogs also received 20 mg/kg of L-NAME, LPS caused mean arterial pressure (MAP), flow and QO2 to whole body, hindlimb and gut to decrease, but O2 uptake (VO2) did not change. Dextran resuscitation alone produced a hyperdynamic state with increased blood flow to or above baseline. With L-NAME, systemic and regional resistances increased twofold and MAP returned to near baseline. Late in the study, these dogs had significantly lower blood flow and QO2 to the gut but maintained VO2 by increasing oxygen extraction to near critical levels. These data suggest that in acute endotoxicosis, L-NAME may significantly improve blood pressure but may markedly encroach on O2 transport reserves to the gut.
ISSN:1073-2322
1540-0514