Clinicopathologic features and prognosis of resected hepatocellular carcinomas of varied sizes with special reference to proliferating cell nuclear antigen

Background. Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activi...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1995-08, Vol.76 (3), p.399-405
Main Authors: Suehiro, Taketoshi, Matsumata, Takashi, Itasaka, Hidetoshi, Yamamoto, Kazuharu, Kawahara, Naoyuki, Sugimachi, Keizo
Format: Article
Language:English
Subjects:
Antigens, Neoplasm - analysis
Biological and medical sciences
Carcinoma, Hepatocellular - immunology
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Cell Division
Female
Gastroenterology. Liver. Pancreas. Abdomen
hepatocellular carcinoma
Humans
immunohisto‐chemistry
Liver Neoplasms - immunology
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Prognosis
proliferating cell nuclear antigen
Proliferating Cell Nuclear Antigen - analysis
Survival Rate
tumor size
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activity of cancer cells and prognosis. Methods. One hundred forty‐one neoplasms resected from 141 patients who underwent hepatic surgery for HCC at Kyushu University hospital from April, 1991, to July, 1993, were studied immunohistochemically using monoclonal antibody for PCNA (PC10), and analyzed for a possible correlation between PCNA labeling index (PCNA‐LI) and the prognosis of patients with HCC. Results. Proliferating cell nuclear antigen reactive cancer cells were observed throughout the HCC. The PCNA‐LI ranged from 1.2%‐91.6%, with a mean of 37.7%. The high PCNA‐LI (>37.7) group showed a significantly higher incidence of tumor thrombus in the portal vein, higher Edmondson's Grade, and a higher recurrence rate than the low PCNA‐LI (
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19950801)76:3<399::AID-CNCR2820760309>3.0.CO;2-O