COMPARATIVE STUDIES ON ACTIVITIES OF ANTIMICROBIAL AGENTS AGAINST CAUSATIVE ORGANISMS ISOLATED FROM URINARY TRACT INFECTIONS (1993): I. SUSCEPTIBILITY DISTRIBUTION

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 657 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1993 to May 1994. Of the above total bacterial isolates, Gram-positive bacteria accounte...

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Published in:Japanese journal of antibiotics 1995/11/25, Vol.48(11), pp.1757-1787
Main Authors: KUMAMOTO, YOSHIAKI, HIROSE, TAKAOKI, TANAKA, NORIAKI, HIKICHI, YOSHINAO, SHIGETA, SHIRO, SHIRAIWA, YASUO, KAMEOK, HIROSHI, YOSHIDA, HIROSHI, TAZAKI, HIROSHI, IRI, HISAMI, UCHIDA, HIROSHI, KOBAYASHI, YOSHIO, MATSUDA, SEIJI, KITAGAWA, RYUICHI, FUJIME, MAKOTO, FUJITA, KAZUHIKO, IGARI, JUN, OGURI, TOYOKO, KOSAKAI, NOZOMU, YAMAGUCHI, KEIZO, MOCHIDA, CHIKAKO, FURUSAWA, TARO, TAKEUCHI, YASUKO, MORIYAMA, HIROMI, SHIBATA, KIKUTARO, YONEZU, SEIBUN, TAKAHA, MINATO, MATSUMIYA, KIYOMI, TANAKA, MICHIO, KAKU, MITSUO, SUGAWARA, KAZUYUKI
Format: Article
Language:Japanese
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - isolation & purification
Bacterial Infections - microbiology
Enterococcus faecalis - drug effects
Escherichia coli - drug effects
Humans
Microbial Sensitivity Tests
Urinary Tract Infections - microbiology
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Summary:The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 657 bacterial strains isolated from patients with urinary tract infections in 10 hospitals during the period of June 1993 to May 1994. Of the above total bacterial isolates, Gram-positive bacteria accounted for 28.3% and a majority of them were Enterococcus faecalis. Gram-negative bacteria accounted for 71.7% and most of them were Escherichia coll. 1.Enterococcus faecalis Ampicillin (ABPC), imipenem (IPM) and vancomycin (VCM) showed the highest activities against E. faecalis isolated from patients with urinary tract infections. The MIC90s of them were 2μg/ml. Piperacillin (PIPC) was also active with the MIC90 of 8μg/ml. The others were not so active with the MIC90s of 32μg/ml or above. 2.Staphylococcus aureus including MRSA VCM showed the highest activities against S. aureus isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml. Arbekacin (ABK) was also active with the MIC90 of 2μg/ml. The others were not so active with the MIC90s of 32μg/ml or above. 3.Staphylococcus epidermidis VCM showed the strongest activity against S. epidermidis isolated from patients with urinary tract infections. Its MIC90 was 1μg/ml. ABK was also active with the MIC90 of 4μg/ml. The others except ABPC were not so active with the MIC90s of 32μg/ml or above. 4.Streptococcus agalactiae Most of the agents were active against S. agalactiae isolated from patients with urinary tract infections. Penicillins, cephems, erythromycin (EM), and clindamycin (CLDM) showed the highest activities. The MIC90s of them were 0.25μg/ml or below. Amikacin (AMK) and minocycline (MINO) showed somewhat low activities with the MIC90s of 16μg/ml. 5.Citrobacter freundii IPM showed the highest activities against C. freundii isolated from patients with urinary tract infections. Its MIC90 was 2μg/ml. Cefozopran (CZOP) and gentamicin (GM) were also active with the MIC90s of 8μg/ml. Penicillins and cephems generally were not so active. 6.Enterobacter cloacae IPM and GM sh owed the highest activities against E. cloacae. The MIC90s of them were 1μg/ml. CZOP and tosufloxacin (TFLX) were also active with the MIC90s of 8μg/ml. Penicillins and cephems except CZOP showed lower activities with the MIC90s of 64μg/ml or above. 7.Escherichia coli Most of antimicrob ial agents were active against E. coli. Flomoxef (FMOX), CZOP, IPM, CPFX and TFLX showed the highest activities against E. coli. The MIC90s of them
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.48.1757