Multiple fine-needle biopsies using a coaxial technique : efficacy and a comparison of three methods

Compare the success of three coaxial fine-needle biopsy techniques in obtaining multiple cytologic specimens of high quality. For each of three different biopsy needle and technique combinations (aspiration: 22-gauge Chiba; capillary: 22-gauge Chiba; 22-gauge Autovac aspiration biopsy gun), 30 sites...

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Bibliographic Details
Published in:Cardiovascular and interventional radiology 1995-09, Vol.18 (5), p.307-311
Main Authors: HOPPER, K. D, ABENDROTH, C. S, TENHAVE, T. R, HARTZEL, J, SAVAGE, C. A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biopsy, Needle - instrumentation
Biopsy, Needle - methods
Equipment Design
Humans
Investigative techniques, diagnostic techniques (general aspects)
Kidney - pathology
Liver - pathology
Logistic Models
Medical sciences
Miscellaneous. Technology
Needles
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
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Summary:Compare the success of three coaxial fine-needle biopsy techniques in obtaining multiple cytologic specimens of high quality. For each of three different biopsy needle and technique combinations (aspiration: 22-gauge Chiba; capillary: 22-gauge Chiba; 22-gauge Autovac aspiration biopsy gun), 30 sites (15 liver, 15 kidney) were selected for coaxial fine-needle biopsy in cadaveric liver and kidneys. For each coaxial technique, three sequential biopsies were performed through an 18-gauge coaxial needle at each of multiple sites. The quality of the resultant 270 specimens was graded by a blinded cytopathologist using a previously published grading scheme. Using the coaxial technique, there was no significant dropoff in the cytologic specimen quality among the first, second, and third biopsies at a specific site, regardless of the order of the techniques/needles used. This was true for organs, the overall data, and for the individual five grading criteria. There was, however, a significant difference among the biopsy techniques themselves. Though there was no difference in the quality of cytopathologic specimen obtained with the Autovac aspiration gun and the aspiration technique with a 22-gauge Chiba needle, both were statistically better than the nonaspiration, capillary technique utilizing a 22-gauge needle (p = 0.0001). The use of a coaxial technique with a fine-needle, 22-gauge biopsy offers unique advantages in obtaining a nearly unlimited amount of high-quality material for cytopathologic analysis. In this study, no dropoff was found in specimen quality with subsequent biopsies.
ISSN:0174-1551
1432-086X
DOI:10.1007/BF00203681