Drug-induced changes in renal hippurate clearance as a measure of renal blood flow

Drug-induced changes in renal hippurate clearance as a measure of renal blood flow. We studied the accuracy of the plasma 131I-hippurate clearance technique to monitor drug-induced changes in renal blood flow (RBF) by comparing it to a flow probe technique in six conscious, chronically instrumented...

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Bibliographic Details
Published in:Kidney international 1995-11, Vol.48 (5), p.1617-1623
Main Authors: Visscher, C. Antoinette, de Zeeuw, Dick, de Jong, Paul E., Sluiter, Wim J., Huisman, Roel M.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - drug effects
Dogs
Hematocrit
Hippurates - pharmacokinetics
Investigative techniques, diagnostic techniques (general aspects)
Kidney - drug effects
Kidney - metabolism
Male
Medical sciences
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Regression Analysis
Renal Circulation
Stimulation, Chemical
Urinary system
Vascular Resistance - drug effects
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Summary:Drug-induced changes in renal hippurate clearance as a measure of renal blood flow. We studied the accuracy of the plasma 131I-hippurate clearance technique to monitor drug-induced changes in renal blood flow (RBF) by comparing it to a flow probe technique in six conscious, chronically instrumented dogs. Placebo caused no change in RBF, either established by hippurate clearance (ERPFhip) or by renal blood flow probe (RBFprobe). Enalaprilate induced a rise in ERPFhip and RBFprobe (+26 ± 5 and 44 ± 12%), as did dopamine (+16 ± 4 and +33 ± 5%). Intravenous infusion of norepinephrine induced a rise in ERPFhip (+2 ± 6%, NS) and in RBFprobe (+18 ± 3%), as did nitroprusside (+14 ± 4% and +13 ± 6%, NS). Indomethacin induced a fall in ERPFhip (-8 ± 2%) and in RBFprobe (-7 ± 3%, NS), as did angiotensin II (-19 ± 1 and -26 ± 3%). Renal hippurate extraction (Ehip) was affected by enalaprilate, dopamine, and angiotensin II (-5 ±2, -7 ± 1, and +5 ± 2%, respectively). Hematocrit (Hct) was affected by dopamine, norepinephrine, and nitroprusside (+2 ± 1, +6 ± 1, and - 6 ± 2%, respectively). Drug-induced changes in ERPFhip correlated well with changes in RBFprobe (r = 0.902, P < 0.01). Changes in Ehip did not independently affect this relation, whereas changes in Hct did: ΔRBF(% of baseline) = 1.529 × ΔERPFhip(% of baseline) + 1.296 × ΔHct(% of baseline). These data indicate that drug-induced changes in plasma hippurate clearance can, even when changes in renal hippurate extraction are unknown, be used as a reliable indicator of changes in renal blood flow if changes in hematocrit are taken into account.
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1995.456