Serotonin in attempted suicide

Considers reviews of post-mortem brain studies of suicide victims, in half of which reduced levels of 5-HT and of its metabolite 5-HIAA were established. Concluded that there is a reduction of presynaptic 5-HT activity in the brain, with a compensatory post-synaptic up-regulation of the number of 5-...

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Bibliographic Details
Published in:Journal of psychosomatic research 1994-10, Vol.38 (7), p.639-641
Main Author: Hengeveld, M.W.
Format: Article
Language:English
Subjects:
Blood Platelets - metabolism
Fenfluramine - agonists
Humans
Hydroxyindoleacetic Acid - cerebrospinal fluid
Hydroxyindoleacetic Acid - metabolism
Parasuicide
Role
Serotonin
Serotonin - cerebrospinal fluid
Serotonin - metabolism
Suicide, Attempted
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Summary:Considers reviews of post-mortem brain studies of suicide victims, in half of which reduced levels of 5-HT and of its metabolite 5-HIAA were established. Concluded that there is a reduction of presynaptic 5-HT activity in the brain, with a compensatory post-synaptic up-regulation of the number of 5-HT2 receptor sites. Changes in 5-HT metabolism are not associated with any specific major psychiatric disorder. (Original abstract-amended)
ISSN:0022-3999
1879-1360
DOI:10.1016/0022-3999(94)90016-7