Herpesvirus-like DNA Sequences in Non-AIDS Kaposi's Sarcoma

The pathogenesis of Kaposi's sarcoma (KS) is suggested to be related to an infectious agent transmitted by sexual contact. Recently, DNA sequences homologous to γ herpesviridae have been identified in AIDS-associated KS, but no information is available concerning non-AIDS-associated KS. Five cl...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-12, Vol.172 (6), p.1605-1607
Main Authors: de Lellis, Laura, Fabris, Marina, Cassai, Enzo, Corallini, Alfredo, Giraldo, Gaetano, Feo, Carlo, Monini, Paolo
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
AIDS
AIDS/HIV
Biological and medical sciences
Concise Communications
Dermatology
DNA, Viral - analysis
Herpesviridae
Herpesviridae - genetics
herpesvirus
Humans
Kaposi sarcoma
Lesions
Lymph nodes
Medical sciences
Nucleotide sequences
Peripheral blood mononuclear cells
Polymerase Chain Reaction
Sarcoma, Kaposi - virology
Specimens
Tumors of the skin and soft tissue. Premalignant lesions
Viruses
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Summary:The pathogenesis of Kaposi's sarcoma (KS) is suggested to be related to an infectious agent transmitted by sexual contact. Recently, DNA sequences homologous to γ herpesviridae have been identified in AIDS-associated KS, but no information is available concerning non-AIDS-associated KS. Five classic, 12 endemic, and 17 AIDS-associated KS skin lesion specimens were analyzed and all were positive for these novel DNA sequences. Twenty-four specimens from normal skin were negative. These novel sequences were also found in lymph nodes from human immunodeficiency virus-positive patients with AIDS or lymphadenopathy syndrome but not in peripheral blood mononuclear cells from normal subjects. Therefore, the data support the view that a novel γ herpesvirus might be specifically associated with KS etiopathogenesis.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/172.6.1605