Maintenance of Donor Phenotype After Full-Thickness Skin Transplantation from Mice with Chronic Proliferative Dermatitis (cpdm/dpdm) to C57BL/Ka and Nude Mice and Vice Versa

Chronic proliferative dermatitis is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm) and is characterized by epithelial hyperproliferation, infiltration by eosinophils and macrophages, and vascular dilatation. To elucidate whether these pathologic features are the result of a local (skin) process...

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Bibliographic Details
Published in:Journal of investigative dermatology 1995-12, Vol.105 (6), p.769-773
Main Authors: Gijbels, Marion J.J., HogenEsch, Harm, Bruijuzeel, Piet L.B., Elliott, Graham R., Zurcher, Chris
Format: Article
Language:English
Subjects:
Animals
Bromodeoxyuridine - metabolism
Cell Division
Chronic Disease
dermatitis
Dermatitis - genetics
Dermatitis - pathology
Female
Intercellular Adhesion Molecule-1 - analysis
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Mice, Nude
mouse model
Phenotype
skin
Skin Transplantation
transplantation
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Summary:Chronic proliferative dermatitis is a spontaneous mutation in C57BL/Ka mice (cpdm/cpdm) and is characterized by epithelial hyperproliferation, infiltration by eosinophils and macrophages, and vascular dilatation. To elucidate whether these pathologic features are the result of a local (skin) process or a consequence of a systemic disorder, transplantations were performed of full-thickness grafts of affected skin from cpdm/cpdm mice and normal skin from control (C57BL/Ka) mice on the back of cpdm/cpdm, C57BL/Ka and athymic nude mice. After 3 months, the grafts maintained the histologic phenotype of the donor animal. Intercellular adhesion molecule-1 continued to be expressed by basal keratinocytes of the cpdm/cpdm grafts after transplanation. In contrast the basal keratinocytes of the C57BL/Ka grafts onto cpdm/cpdm mice remained negative for intercellular adhesion molecule-1 3 months after transplantation. An increased number of proliferating keratinocytes was present in the cpdm/cpdm skin-graft transplanted to nudes or to C57BL/Ka mice based on short-term bromodeoxyuridine labeling. The bromodeoxyuridine incorporation in the keratinocytes of the control C57BL/Ka skin grafts transplanted to cpdm/cpdm, nude, or C57BL/Ka mice was the same as in the keratinocytes of normal C57BL/Ka mice. This study demonstrates that the pathological features found in the cpdm/cpdm mice are the result of a disorder in the epidermis or dermis and not due to systemic defect.
ISSN:0022-202X
1523-1747
DOI:10.1111/1523-1747.ep12325599