Antioxidative vitamin treatment: Effect on lipid peroxidation and limb swelling after revascularization operations

The objective of this study was to evaluate the antioxidative properties of the multivitamin cocktail Omnibionta® (α‐tocopherol, ascorbic acid, retinol, vitamin B complex) in terms of diminishing lipid peroxidation with improvement of leg edema performance after limb revascularization operations in...

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Bibliographic Details
Published in:World journal of surgery 1995-09, Vol.19 (5), p.738-744
Main Authors: Rabl, H., Khoschsorur, G., Petek, W.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antioxidants - administration & dosage
Base Pendant
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
General and cellular metabolism. Vitamins
Humans
Ischemia - surgery
Leg - blood supply
Lipid Peroxidation
Lipid Peroxidation - drug effects
Lymphedema - prevention & control
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Postoperative Complications - prevention & control
Prevent Lipid Peroxidation
Reactive Oxygen Species - metabolism
Reperfusion Injury - prevention & control
Retinol
Revascularization Operation
Treatment Outcome
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Summary:The objective of this study was to evaluate the antioxidative properties of the multivitamin cocktail Omnibionta® (α‐tocopherol, ascorbic acid, retinol, vitamin B complex) in terms of diminishing lipid peroxidation with improvement of leg edema performance after limb revascularization operations in humans. Fifty‐one subjects were selected; the control group contained 27 patients and the treatment group 24 patients, who received the vitamin cocktail intravenously before the start of reperfusion. All patients suffered from acute or chronic arterial occlusive disease, except two subjects with arterial trauma. MDA‐TBARS in plasma, quantified by HPLC, taken as a measure of lipid peroxidation was significantly increased (p
ISSN:0364-2313
1432-2323
DOI:10.1007/BF00295919