CEFUZONAM, NEW CEPHEM ANTIBIOTIC IN FIELD OF PEDIATRICS CONCENTRATIONS IN SERUM AND CLINICAL EFFICACY

A new cephem antibiotic, cefuzonam (L-105, CZON) was studied for its concentrations in serum and clinical efficacy in the field of pediatrics. 1. To examine the concentration of CZON in serum, 20 mg/kg of CZON was administered by intravenous drip infusion to a male patient of 6 years and 7 months. T...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1987/03/25, Vol.40(3), pp.680-684
Main Authors: OGURA, HIDEO, TOMODA, TAKASHI, HAMADA, FUMIHIKO, FUJIEDA, MIKIYA, OHARA, YUJI, ARAKI, KUMIKO, KITAMURA, ISAMU
Format: Article
Language:Japanese
Subjects:
Bacterial Infections - drug therapy
Ceftizoxime - analogs & derivatives
Cephalosporins - blood
Cephalosporins - therapeutic use
Child
Child, Preschool
Drug Evaluation
Female
Humans
Infant
Male
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Summary:A new cephem antibiotic, cefuzonam (L-105, CZON) was studied for its concentrations in serum and clinical efficacy in the field of pediatrics. 1. To examine the concentration of CZON in serum, 20 mg/kg of CZON was administered by intravenous drip infusion to a male patient of 6 years and 7 months. The half-life of the drug in serum was 0.97 hour after administration. 2. CZON was administered to 7 cases of pediatric infections, and clinical result were “excel-lent” in 4, “good” in 1, “poor” in 2: the efficacy rate was 71.4% or 5 cases out of 7. As an adverse reaction, eruption was observed in 1 patient
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.40.680