Immunomodulatory Action of Somatostatin

The influence of somatostatin (SST) on spontaneous proliferation and cyclic AMP level in mouse spleen lymphocytes and on inhibition of human leukocyte migration was studied. The rate of [3H]thymidine incorporation was used as an index of proliferation. It was found that lower concentrations of SST/1...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 1987-05, Vol.496 (1), p.233-239
Main Authors: PAWLIKOWSKI, MAREK, STĘPIEṄ, HENRYK, KUNERT-RADEK, JOLANTA, ŻELAZOWSKI, PIOTR, SCHALLY, ANDREW V.
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Animals
Chemotaxis, Leukocyte - drug effects
Cyclic AMP - metabolism
Humans
Hypothalamus - physiology
In Vitro Techniques
Lymphocyte Activation - drug effects
Lymphocytes - drug effects
Lymphocytes - immunology
Lymphocytes - metabolism
Mice
Somatostatin - immunology
Somatostatin - pharmacology
Spleen - immunology
Tissue Extracts - pharmacology
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Summary:The influence of somatostatin (SST) on spontaneous proliferation and cyclic AMP level in mouse spleen lymphocytes and on inhibition of human leukocyte migration was studied. The rate of [3H]thymidine incorporation was used as an index of proliferation. It was found that lower concentrations of SST/10(-9) and 10(-8)M, inhibited the splenocyte proliferation. In contrast, a higher SST concentration, 10(-7)M, exerted a stimulatory effect. SST in concentrations from 10(-9) to 10(-6)M did not influence cyclic AMP levels in mouse splenocytes; a significant decrease of cyclic AMP was found after the exposure to superactive SST analog RC-102-2H in concentrations 10(-8) and 10(-7)M. SST, 10(-7)M, and RC-102-2H, 10(-7)M, significantly enhanced the migration inhibition of human leukocytes induced by the exposure of leukocytes to cardiac antigen or phytohemagglutinin. The data provide evidence for an immunomodulatory action of SST.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.1987.tb35771.x