Regulation of scytophycin accumulation in cultures of Scytonema ocellatum. II: Nutrient requirements

The effects of optimal sources and concentrations of major nutrients (supplying N, S, P, K+, Na+, Ca2+, Mg2+, and inorganic carbon) and organic buffers on growth and secondary metabolite accumulation in Scytonema ocellatum strain FF-66-3 were determined. Nitrate, phosphate, magnesium, and sulfur had...

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Published in:Applied microbiology and biotechnology 1995-09, Vol.43 (4), p.692-700
Main Authors: PATTERSON, G. M. L, BOLIS, C. M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Bacteriology
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biotechnology
Calcium - pharmacology
Cyanobacteria - growth & development
Cyanobacteria - metabolism
Fundamental and applied biological sciences. Psychology
Macrolides
Magnesium - pharmacology
Microbiology
Mission oriented research
Nitrogen - metabolism
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Phosphates - pharmacology
Physiology and metabolism
Potassium - pharmacology
Pyrans - metabolism
Scytonema ocellatum
Sodium - pharmacology
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Summary:The effects of optimal sources and concentrations of major nutrients (supplying N, S, P, K+, Na+, Ca2+, Mg2+, and inorganic carbon) and organic buffers on growth and secondary metabolite accumulation in Scytonema ocellatum strain FF-66-3 were determined. Nitrate, phosphate, magnesium, and sulfur had no specific stimulatory or inhibitory effects on scytophycin accumulation within the range of concentrations that supported optimal growth. Calcium concentrations greater than those required for growth (0.1 mM) stimulated scytophycin accumulation. Sodium carbonate concentrations in excess of 0.25 mM strongly inhibited growth. Ammonium (2.5 mM) inhibited both growth and product formation. 3-[N-Morpholino]propanesulfonic acid at 3-5 mM effectively controlled pH and facilitated both growth and product formation.
ISSN:0175-7598
1432-0614
DOI:10.1007/BF00164775