Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.

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Bibliographic Details
Published in:Nature (London) 1987-07, Vol.328 (6125), p.38-43
Main Authors: Piomelli, D, Volterra, A, Dale, N, Siegelbaum, S. A, Kandel, E. R, Schwartz, J. H, Belardetti, F
Format: Article
Language:English
Subjects:
Animals
Aplysia
Aplysia - physiology
Arachidonic Acid
Arachidonic Acids - metabolism
Arachidonic Acids - pharmacology
Biological and medical sciences
Biology
Chemistry
Electrophysiology
FMRFamide
Fundamental and applied biological sciences. Psychology
Hydroxy Acids - metabolism
Hydroxyeicosatetraenoic Acids - physiology
inhibitors
Invertebrates
Ion Channels - drug effects
Ion Channels - physiology
Leukotrienes
Lipoxygenase - metabolism
Marine
metabolites
Mollusca
neurons
Neurons, Afferent - drug effects
Neurons, Afferent - physiology
Neuropeptides - pharmacology
Phospholipases - antagonists & inhibitors
Physiology. Development
sensory neurons
Synapses - physiology
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Description
Summary:Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid. These compounds are a new class of second messengers in neurons.
ISSN:0028-0836
1476-4687
DOI:10.1038/328038a0