The appearance of active plasminogen activator of urokinase type (u-PA) in the rabbit anterior eye segment irradiated by UVB rays. A histochemical and biochemical study

Repeated irradiation of the rabbit eye with UV rays of 312 nm wavelength (UVB) evoked the appearance of active plasminogen activator of urokinase type (u-PA) in the anterior eye segment. Using histochemistry, active u-PA appeared first in the corneal epithelium followed by the corneal endothelium, i...

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Bibliographic Details
Published in:Acta histochemica 1995-07, Vol.97 (3), p.257-262
Main Authors: Čejková, Jitka, Lojda, Zdenek
Format: Article
Language:English
Subjects:
active u-PA
Amino Acid Sequence
Animals
Anterior Eye Segment - enzymology
Anterior Eye Segment - radiation effects
Aqueous Humor - enzymology
Aqueous Humor - radiation effects
eye
Histocytochemistry
Molecular Sequence Data
rabbit
Rabbits
Tears - enzymology
Tears - radiation effects
Ultraviolet Rays
Urokinase-Type Plasminogen Activator - analysis
Urokinase-Type Plasminogen Activator - radiation effects
UVB rays
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Summary:Repeated irradiation of the rabbit eye with UV rays of 312 nm wavelength (UVB) evoked the appearance of active plasminogen activator of urokinase type (u-PA) in the anterior eye segment. Using histochemistry, active u-PA appeared first in the corneal epithelium followed by the corneal endothelium, inflammatory cells in the corneal stroma and the lens epithelium. With a semiquantitative fluorescent method active u-PA was also found in the tear fluid and aqueous humour. UV rays of 365 nm wavelength (UVA) under the same conditions did not cause the appearance of active u-PA in the anterior eye segment.
ISSN:0065-1281
1618-0372
DOI:10.1016/S0065-1281(11)80186-8