Dietary restriction

Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging a...

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Bibliographic Details
Published in:Experimental gerontology 1995-05, Vol.30 (3), p.291-298
Main Author: Masoro, Edward J.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
biological age
Blood Glucose - metabolism
carbohydrate metabolism
Circadian Rhythm - physiology
Corticosterone - blood
Diet
dietary restriction
Endocrine Glands - physiology
Energy Intake
glucocorticoids
glycemia
Gompertz analysis
heat shock proteins
insulinemia
Male
metabolic rate
Mice
Models, Biological
Nervous System Physiological Phenomena
Phenotype
Rats
Rats, Inbred F344
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Summary:Dietary restriction (DR) slows the rate of actuarial aging of rats and mice and in addition retards and/or delays many phenotypic characteristics of aging such as the age-associated deterioration of physiological systems and the occurrence and progression of age-associated disease. These antiaging actions result from a reduction of energy intake by the animal but are not due to a decrease in metabolic rate per unit of lean body mass. However, there is evidence that altered characteristics of fuel use (but not the intensity of fuel use) may underlie the antiaging action of DR. There is also evidence that DR has a general protective action in regard to damage caused by acute stressors; possibly a similar protective action in regard to damage caused by prolonged, low intensity aging processes plays a major role in the antiaging action of DR.
ISSN:0531-5565
1873-6815
DOI:10.1016/0531-5565(94)00028-2