1-(Fluorobenzyl)-4-amino-1H-1,2,3-triazolo[4,5-c]pyridines: Synthesis and Anticonvulsant Activity

A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 w...

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Bibliographic Details
Published in:Journal of medicinal chemistry 1995-09, Vol.38 (20), p.4131-4134
Main Authors: Kelley, James L, Koble, Cecilia S, Davis, Ronda G, McLean, Ed W, Soroko, Francis E, Cooper, Barrett R
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - chemical synthesis
Anticonvulsants - pharmacology
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Dogs
Male
Medical sciences
Neuropharmacology
Pharmacology. Drug treatments
Rats
Structure-Activity Relationship
Triazoles - chemical synthesis
Triazoles - pharmacology
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Summary:A series of (fluorobenzyl)triazolo[4,5-c]pyridines was synthesized and tested for activity against maximal electroshock-induced seizures in rodents. The most promising compound, 14 (BW 534U87), which is a carbon-nitrogen isoster of a purine anticonvulsant, has a profile in rodents that suggests 14 will be free of emesis and useful in the treatment of seizure disorders for which phenytoin is presently indicated.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00020a030