Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase

A full-length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH 1) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino-terminal end of ALDH I and other known targeting sequences responsible for protein uptake...

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Bibliographic Details
Published in:FEBS letters 1987-05, Vol.215 (2), p.233-236
Main Authors: Braun, Thomas, Bober, Eva, Singh, Surjit, Agarwal, Dharam P., Goedde, H.Werner
Format: Article
Language:English
Subjects:
aldehyde dehydrogenase
Aldehyde Dehydrogenase - analysis
Aldehyde dehydrogenase I
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
cDNA
cDNA sequence
Cloning, Molecular
DNA - analysis
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
genes
Human
Humans
Leader peptide
man
mitochondria
Mitochondria - enzymology
nucleotide sequence
Oxidoreductases
Protein Sorting Signals - analysis
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Summary:A full-length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH 1) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino-terminal end of ALDH I and other known targeting sequences responsible for protein uptake into the mitochondria.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(87)80152-7