Dopaminergic parameters in the striatum and substantia nigra of seven strains of mice: higher density in striatum of CAST compared to BALB mice

Tyrosine hydroxylase activity was assayed in microdissected substantia nigra and striata from seven strains of mice (BALB, CBA, YBR, WB, IS, MOLG, and CAST). In the substantia nigra where tyrosine hydroxylase activity is thought to be proportional to dopaminergic neuron number, only CBA had a differ...

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Bibliographic Details
Published in:Neurochemical research 1995-04, Vol.20 (4), p.395-400
Main Authors: Richter, J A, Brenneman, M G, Dlouhy, S R, Ghetti, B
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - metabolism
Dopamine - physiology
Glutamate Decarboxylase - metabolism
Mice
Mice, Inbred BALB C - metabolism
Muridae - metabolism
Serotonin - metabolism
Species Specificity
Substantia Nigra - metabolism
Tyrosine 3-Monooxygenase - metabolism
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Summary:Tyrosine hydroxylase activity was assayed in microdissected substantia nigra and striata from seven strains of mice (BALB, CBA, YBR, WB, IS, MOLG, and CAST). In the substantia nigra where tyrosine hydroxylase activity is thought to be proportional to dopaminergic neuron number, only CBA had a different (lower) enzyme activity compared with BALB. However in the striatum, tyrosine hydroxylase activity was larger for IS, MOLG and CAST compared with BALB. Further investigation of the CAST striatum showed that dopamine content and dopamine uptake activity were also higher in comparison with BALB. All three dopaminergic parameters were larger because of lower protein levels in the CAST striatum. A lower absolute amount of glutamic acid decarboxylase activity in CAST versus BALB striatum was consistent with the possibility of a smaller CAST striatum. In contrast to dopamine, the serotonin content in CAST striatum was reduced in proportion to the decrease in protein content. We suggest that the CAST striatum is smaller than BALB striatum and is innervated by proportionally fewer serotoninergic terminals, but the amount of dopaminergic innervation of the CAST striatum is not altered by the size of the target.
ISSN:0364-3190
1573-6903
DOI:10.1007/BF00973093