Glandular cardiac myxomas histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation

Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid‐Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidas...

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Bibliographic Details
Published in:Cancer 1987-05, Vol.59 (10), p.1767-1775
Main Authors: Goldman, Bruce I., Frydman, Cheryl, Harpaz, Noam, Ryan, Stephen F., Loiterman, David
Format: Article
Language:English
Subjects:
Adult
Aged
Antigens - analysis
Biological and medical sciences
Carcinoembryonic Antigen - analysis
Cardiology. Vascular system
Epithelium - pathology
Factor VIII - analysis
Factor VIII - immunology
Female
Heart
Heart Neoplasms - immunology
Heart Neoplasms - pathology
Histocytochemistry
Humans
Immunoenzyme Techniques
Keratins - analysis
Male
Medical sciences
Membrane Proteins - analysis
Microscopy, Electron
Mucin-1
Myxoma - immunology
Myxoma - pathology
Tumors of the heart
von Willebrand Factor
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Summary:Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid‐Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstrated positivity of the glandular cells for carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), and keratin. Factor VIII‐related antigen (FVIIIAg) was identified only in cells lining vascular spaces. Electron microscopic study of one tumor demonstrated well‐formed glands having basement membranes, junctional complexes, and apical secretory granules. These findings indicate the capacity for true epithelial differentiation of cardiac myxomas and have implications both as regards the histologic diagnosis of these tumors and their histogenesis.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870515)59:10<1767::AID-CNCR2820591015>3.0.CO;2-U