TUBOCURARINE AND PANCURONIUM INHIBIT EVOKED RELEASE OF ACETYLCHOLINE FROM THE MOUSE HEMIDIAPHRAGM PREPARATION

Using a sensitive radioactive method that measures selectively the evoked release of acetylcholine, it was demonstrated that, when stimulating at 50 Hz, tubocurarine or pan-curonium 2×10* mo I litrel or hexamethonium 10−3 mol litre−1 significantly decreased the evoked release of acetylcholine in the...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1987-02, Vol.59 (2), p.226-231
Main Authors: VIZI, E.S., SOMOGYI, G.T., NAGASHIMA, H., DUNCALF, D., CHAUDHRY, I.A., KOBAYASHI, O., GOLDINER, P.L., FOLDES, F.F.
Format: Article
Language:English
Subjects:
Acetylcholine - metabolism
Anesthetics. Neuromuscular blocking agents
Animals
Biological and medical sciences
Depression, Chemical
Diaphragm - physiology
Hexamethonium
Hexamethonium Compounds - pharmacology
In Vitro Techniques
Male
Medical sciences
Mice
Muscle Contraction - drug effects
Neuromuscular Junction - drug effects
Neuropharmacology
Pancuronium - pharmacology
Pharmacology. Drug treatments
Tubocurarine - pharmacology
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Summary:Using a sensitive radioactive method that measures selectively the evoked release of acetylcholine, it was demonstrated that, when stimulating at 50 Hz, tubocurarine or pan-curonium 2×10* mo I litrel or hexamethonium 10−3 mol litre−1 significantly decreased the evoked release of acetylcholine in the mouse in vitro phrenic preparation.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/59.2.226