Disseminated Acanthamoeba Infection in Patients with AIDS: Case Reports and Review

Acanthamoeba infection has been described as an opportunistic infection in persons with AIDS. We report two cases of patients with AIDS and acanthamoeba infection and review the manifestations of this protozoan infection in patients infected with human immunodeficiency virus. The diagnosis of this i...

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Bibliographic Details
Published in:Clinical infectious diseases 1995-05, Vol.20 (5), p.1207-1216
Main Authors: Sison, Jeanette P., Kemper, Carol A., Loveless, Mark, McShane, Dennis, Visvesvara, Govinda S., Deresinski, Stanley C.
Format: Article
Language:English
Subjects:
Acanthamoeba
Acanthamoeba - cytology
Acanthamoeba - ultrastructure
Acanthamoeba keratitis
Adult
AIDS
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - therapy
AIDS/HIV
Amebiasis - diagnosis
Amebiasis - therapy
Amoeba
Animals
Biological and medical sciences
Clinical Articles
Cysts
Encephalitis
Fungal infections
human immunodeficiency virus
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infections
Lesions
Male
Medical sciences
Nodules
Trophozoites
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Description
Summary:Acanthamoeba infection has been described as an opportunistic infection in persons with AIDS. We report two cases of patients with AIDS and acanthamoeba infection and review the manifestations of this protozoan infection in patients infected with human immunodeficiency virus. The diagnosis of this infection requires a high index of suspicion because the clinical and histologic manifestations may be confused with those of disseminated fungal or algal disease. Clinicians and laboratory personnel should be aware of this potentially fatal condition so that appropriate diagnostic studies can be performed and treatment can be urgently administered. Early initiation of therapy may alter the clinical outcome of the disease.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/20.5.1207