Chlamydia pneumoniae-Induced Ciliostasis in Ciliated Bronchial Epithelial Cells

The ciliary activity of ciliated bronchial epithelial cells was studied after infection with Chlamydia pneumoniae (strain TW-183) and Chlamydia trachomatis (biovar L2 [434/Bu]). C. pneumoniae, known to cause respiratory infections, had a marked ciliastatic effect, completely aborting ciliary motion...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-05, Vol.171 (5), p.1274-1278
Main Authors: Shemer-Avni, Yonat, Lieberman, David
Format: Article
Language:English
Subjects:
Antibodies, Bacterial
Antigens
Antigens, Bacterial - immunology
Bacteriology
Biological and medical sciences
Bronchi - cytology
Bronchi - microbiology
Bronchi - physiology
Bronchitis
Bronchoscopy
Cell Movement - radiation effects
Cells, Cultured
Chlamydia
Chlamydia pneumoniae
Chlamydia trachomatis - immunology
Chlamydia trachomatis - physiology
Chlamydophila pneumoniae - immunology
Chlamydophila pneumoniae - physiology
Cilia - physiology
Cultured cells
Epithelial cells
Fundamental and applied biological sciences. Psychology
Hot Temperature
Humans
Inclusion Bodies
Infections
Major Articles
Microbiology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Respiratory tract infections
Seeding
Species Specificity
Ultraviolet Rays
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Summary:The ciliary activity of ciliated bronchial epithelial cells was studied after infection with Chlamydia pneumoniae (strain TW-183) and Chlamydia trachomatis (biovar L2 [434/Bu]). C. pneumoniae, known to cause respiratory infections, had a marked ciliastatic effect, completely aborting ciliary motion within 48 h. This effect was not inhibited by inactivation of C. pneumoniae elementary bodies (EBs) by UV irradiation. In contrast, inactivation of EBs by heat (56°C, 30 min) or by rabbit-specific immune sera to TW-183 antigen blocked the ciliastatic effect induced by C. pneumoniae infection. The effect of C. pneumoniae was specific. C. trachomatis, which causes sexually transmitted disease, did not block ciliary motion by 48 h after infection. A decrease in ciliary activity of ciliated bronchial cells produced by C. pneumoniae can contribute to both initiation and pathogenesis of respiratory infections induced by this pathogen.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.5.1274