An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains

The concentrations of selected metabolites in the posterior temporoparietal cortex of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains (of individuals between the ages of 63 and 95) were determined using high-resolution 1H nuclear magnetic resonance (NMR) spectroscopy. The es...

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Bibliographic Details
Published in:Experimental brain research 1995, Vol.102 (3), p.503-510
Main Authors: MOHANAKRISHNAN, P, FOWLER, A. H, VONSATTEL, J. P, HUSAIN, M. M, JOLLES, P. R, LIEM, P, KOMOROSKI, R. A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
Aspartic Acid - analogs & derivatives
Aspartic Acid - metabolism
Biological and medical sciences
Creatinine - metabolism
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
gamma-Aminobutyric Acid - metabolism
Glutamic Acid - metabolism
Humans
Inositol - metabolism
Magnetic Resonance Spectroscopy
Male
Medical sciences
Middle Aged
Neurofibrillary Tangles - metabolism
Neurofibrillary Tangles - pathology
Neurology
Parietal Lobe - chemistry
Parietal Lobe - metabolism
Parietal Lobe - pathology
Temporal Lobe - chemistry
Temporal Lobe - metabolism
Temporal Lobe - pathology
Tomography, Emission-Computed, Single-Photon
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Summary:The concentrations of selected metabolites in the posterior temporoparietal cortex of 13 Alzheimer's diseased (AD) and four nondemented postmortem brains (of individuals between the ages of 63 and 95) were determined using high-resolution 1H nuclear magnetic resonance (NMR) spectroscopy. The estimates for glutamate and inositol for AD brains did not show any statistically significant difference (P > 0.05) from those for the nondemented brains. The putative neuronal marker N-acetyl aspartate (NAA), creatine, and GABA were decreased in AD brains compared with the nondemented brains. The estimates for creatine, glutamate, and GABA showed significant linear correlations with those of NAA. Creatine, glutamate, GABA, and NAA appeared to be negatively correlated with the neurofibrillary tangles. Our results support a neuronal loss in the posterior temporoparietal cortices of AD brains.
ISSN:0014-4819
1432-1106
DOI:10.1007/BF00230654