Post-Mortem Neurochemical Changes in Alzheimer's Disease Compared With Normal Ageing

Selective neuronal degeneration with concomitant changes in neurotransmitter systems are features of both normal ageing and Alzheimer's disease. There are, however, important neurochemical differences in cerebral cortex. Choline acetyltransferase declines with age in frontal cortex in contrast...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 1986-11, Vol.13 (S4), p.499-502
Main Authors: Rossor, M., Mountjoy, C.Q.
Format: Article
Language:English
Subjects:
Aging
Alzheimer Disease - metabolism
Biochemical Studies
Humans
Nervous System - metabolism
Neurotransmitter Agents - metabolism
Postmortem Changes
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Summary:Selective neuronal degeneration with concomitant changes in neurotransmitter systems are features of both normal ageing and Alzheimer's disease. There are, however, important neurochemical differences in cerebral cortex. Choline acetyltransferase declines with age in frontal cortex in contrast to the prominent change in the temporal cortex in Alzheimer's disease. The loss of somatostatin, and the recently reported reciprocal change in corticotropin-releasing factor and receptors are not seen with ageing. However, age itself may have an important influence on the neurochemical deficits in Alzheimer's disease which are restricted in the older patients. The problems of post-mortem studies in the analysis of ageing and possible approaches to this are discussed.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100037203