Cholinergic neurones acquire adrenergic neurotransmitters when transplanted into an embryo

During development, cells become progressively restricted, until they reach their final phenotype. Differentiation was originally thought to be irreversible, but phenotypic plasticity has been observed in a variety of cell types, for example sympathetic neurones, the limb blastema and some glial cel...

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Bibliographic Details
Published in:Nature (London) 1986-12, Vol.324 (6097), p.569-572
Main Authors: Coulombe, James Niles, Bronner-Fraser, Marianne
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Catecholamines - metabolism
Cell Differentiation
Chick Embryo
Cholinergic Fibers - metabolism
Cholinergic Fibers - transplantation
Embryology: invertebrates and vertebrates. Teratology
Experimental organogenesis
Fundamental and applied biological sciences. Psychology
Ganglia, Parasympathetic - cytology
Ganglia, Parasympathetic - metabolism
Ganglia, Parasympathetic - transplantation
Neurotransmitter Agents - metabolism
Organogenesis. Physiological fonctions
Phenotype
Quail - embryology
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Summary:During development, cells become progressively restricted, until they reach their final phenotype. Differentiation was originally thought to be irreversible, but phenotypic plasticity has been observed in a variety of cell types, for example sympathetic neurones, the limb blastema and some glial cell types. A detailed description of the individual steps that lead to expression or reversal of phenotype is essential to understand the molecular events underlying cell differentiation. We examined whether ciliary neurones acquire adrenergic properties when exposed to a permissive embryonic environment. Cholinergic neurones were selectively labelled with a retrogradely transported marker and injected into chick embryos during active neural crest migration. Four to five days after injection, some of the labelled neurones were found in 'adrenergic sites' and had developed catecholamine histofluorescence. The cells had thus accumulated adrenergic neurotransmitters even after differentiation into cholinergic neurones. This result shows that neurotransmitter plasticity occurs in cholinergic neurones and suggests that the neurotransmitter phenotype can be modified by the embryonic environment.
ISSN:0028-0836
1476-4687
DOI:10.1038/324569a0