Effect of Fetal Exposure to Ultrasound on the Behavior of the Adult Mouse

Pregnant Swiss albino mice were exposed to diagnostic ultrasound (3.5 MHz, 65 mW, $I_{{\rm SPTP}}=1\ {\rm W}/{\rm cm}^{2}$, $I_{{\rm SATA}}=240\ {\rm W}/{\rm cm}^{2}$) for 10, 20 or 30 min on day 14.5 (fetal period) of gestation. Sham-exposed controls were studied for comparison. Any changes in phys...

Full description

Saved in:
Bibliographic Details
Published in:Radiation research 1995-03, Vol.141 (3), p.314-317
Main Authors: Devi, P. Uma, Suresh, R., Hande, M. P.
Format: Article
Language:English
Subjects:
Adults
Animals
Behavior, Animal
Biological and medical sciences
Brain - physiopathology
Diagnostic ultrasonography
Effects of various physical factors on living matter (vibrations, electric field, ultrasound, sound...)
Female
Fetal stage
Fetus
Fundamental and applied biological sciences. Psychology
Human growth
Memory
Mice
Mortality
Pregnancy
Prenatal Exposure Delayed Effects
Space life sciences
Tissues, organs and organisms biophysics
Ultrasonography
Ultrasonography, Prenatal - adverse effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Pregnant Swiss albino mice were exposed to diagnostic ultrasound (3.5 MHz, 65 mW, $I_{{\rm SPTP}}=1\ {\rm W}/{\rm cm}^{2}$, $I_{{\rm SATA}}=240\ {\rm W}/{\rm cm}^{2}$) for 10, 20 or 30 min on day 14.5 (fetal period) of gestation. Sham-exposed controls were studied for comparison. Any changes in physiological reflexes (such as pinna detachment, opening of the eyes and development of fur), postnatal mortality and changes in adult behavior (open-field test, dark/bright arena test, hole board test and conditioned-avoidance test) were recorded. No change was observed in the physiological reflexes. The postnatal survival was also not affected significantly by the exposure. However, there were significant alterations in behavior in all three exposed groups as revealed by the decreased locomotor and exploratory activity and the increase in the number of trials needed for learning. These results indicate that ultrasound exposure during the early fetal period can impair brain function in the adult mouse.
ISSN:0033-7587
1938-5404
DOI:10.2307/3579009