Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3

Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somat...

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Bibliographic Details
Published in:	Human genetics 1995-03, Vol.95 (3), p.367-369
Main Authors:	BOSCH, A, GUIMERA, J, WIEMANN, S, ANSORGE, W, PATTERSON, D, ESTIVILL, X
Format:	Article
Language:	eng
Subjects:	Base Sequence Biological and medical sciences cell hybrids chromosome 21 Chromosomes, Human, Pair 21 - chemistry Chromosomes, Human, Pair 21 - genetics Classical genetics, quantitative genetics, hybrids DNA Primers DNA, Satellite - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells man Minisatellite Repeats Molecular Sequence Data physical mapping polymorphism Polymorphism, Genetic repeated sequence
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Summary:	Two highly polymorphic CA-repeat microsatellites (D21S1224 and D21S1261) are reported. The clones containing these CA-repeats (ABM-C60 and ABM-C29) have been isolated from a human chromosome-21-specific library (LA21NS01) and have been localised to the q22.3 band using a specific chromosome 21 somatic cell hybrid panel. Both polymorphisms showed heterozygosities of 0.83 in the unrelated reference parents from the Centre d'Etude du Polymorphisme Humain. These new markers should improve the map of the 21q22.3 region, which is believed to contain a large number of genes.
ISSN:	0340-6717 1432-1203