Follicular large cell lymphoma of the testis in a child

Background. A unique case of primary testicular lymphoma in a child is reported. Methods. Tumor tissue was studied using immunohistochemical techniques and southern blot hybridization to detect immunoglobulin and bcl‐2 gene rearrangement and in situ hybridization for the Epstein‐Barr virus (EBV) gen...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 1995-03, Vol.75 (5), p.1182-1186
Main Authors: Moertel, Christopher L., Watterson, Jan, McCormick, Stanley R., Simonton, Susan C.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Child
Diagnosis, Differential
follicular lymphoma
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Gynecology. Andrology. Obstetrics
Herpesvirus 4, Human - genetics
Humans
Immunoenzyme Techniques
In Situ Hybridization
lymphoma
Lymphoma, Follicular - diagnosis
Lymphoma, Follicular - genetics
Male
Male genital diseases
Medical sciences
pediatric lymphoma
testicular lymphoma
testicular neoplasm
Testicular Neoplasms - diagnosis
Testicular Neoplasms - genetics
Tumors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background. A unique case of primary testicular lymphoma in a child is reported. Methods. Tumor tissue was studied using immunohistochemical techniques and southern blot hybridization to detect immunoglobulin and bcl‐2 gene rearrangement and in situ hybridization for the Epstein‐Barr virus (EBV) genome. Results. Light microscopy revealed a lymphocytic infiltrate with a follicular pattern. Immunohistochemical staining revealed lambda light chain restriction and gene rearrangement studies revealed a clonal rearrangement of the immunoglobulin heavy chain, confirming a clonal neoplastic process. Immunostaining failed to detect bcl‐2 protein expression, and no evidence of bcl‐2 gene rearrangement was noted on southern blot analysis. In situ hybridization for EBV nucleic acid in tumor tissue was negative. Conclusions. To the authors' knowledge, this is the first report of a case of a primary testicular lymphoma with follicular histology in a child. Despite the follicular histology, no evidence of bcl‐2 expression or gene rearrangement was detected. Cancer 1995;75:1182–6.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19950301)75:5<1182::AID-CNCR2820750520>3.0.CO;2-Y