Mother-to-infant transmission of hepatitis C virus. Lombardy Study Group on Vertical HCV Transmission

To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p < 0.001) of mothers...

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Bibliographic Details
Published in:The Lancet (British edition) 1995-02, Vol.345 (8945), p.289-291
Main Authors: Zanetti, A R, Tanzi, E, Paccagnini, S, Principi, N, Pizzocolo, G, Caccamo, M L, D'Amico, E, Cambiè, G, Vecchi, L
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS/HIV
Breast Feeding
Female
Follow-Up Studies
Hepacivirus - immunology
Hepatitis Antibodies - blood
Hepatitis C - blood
Hepatitis C - complications
Hepatitis C - transmission
Hepatitis C Antibodies
HIV Infections - complications
HIV Infections - transmission
Humans
Infant, Newborn
Infectious Disease Transmission, Vertical
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Summary:To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p < 0.001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p < 0.05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.
ISSN:0140-6736
1474-547X