Cervical But Not Urinary Excretion Of Cytomegalovirus Is Related To Sexual Activity And Contraceptive Practices In Sexually Active Women

The relationship between sexual activity and genitourinary excretion of cytomegalovirus (CMV) was evaluated in 1481 women at a sexually transmitted disease (STD) clinic. Among 951 who were CMV-seropositive, 16.6% had CMV isolated, from cervix alone in 9.4%, urine alone in 3.8%, and both sites in 4.2...

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Bibliographic Details
Published in:The Journal of infectious diseases 1995-01, Vol.171 (1), p.33-38
Main Authors: Collier, Ann C., Handsfield, H. Hunter, Ashley, Rhoda, Roberts, Pacita L., DeRouen, Tim, Meyers, Joel D., Corey, Lawrence
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Antibodies
Antibodies, Viral - blood
Biological and medical sciences
Cervix uteri
Cervix Uteri - virology
Contraception
Contraception Behavior
Cytomegalovirus
Cytomegalovirus - immunology
Cytomegalovirus - isolation & purification
Cytomegalovirus Infections - complications
Cytomegalovirus Infections - transmission
Cytomegalovirus Infections - virology
Excretion
Female
Gonorrhea - complications
Human sexual behavior
Human viral diseases
Humans
Immunoglobulin M - blood
Infections
Infectious diseases
Major Articles
Medical sciences
Miscellaneous
Regression Analysis
Sexual Behavior
Sexually transmitted diseases
Urinary Tract Infections - virology
Urine
Urine - microbiology
Uterine Cervical Diseases - virology
Viral diseases
Virus Shedding
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Summary:The relationship between sexual activity and genitourinary excretion of cytomegalovirus (CMV) was evaluated in 1481 women at a sexually transmitted disease (STD) clinic. Among 951 who were CMV-seropositive, 16.6% had CMV isolated, from cervix alone in 9.4%, urine alone in 3.8%, and both sites in 4.2%. Isolation rates were highest in young women (P < .001). Compared with those with only cervical infection, women shedding from both cervix and urine were younger, began sexual activity when younger, had more recent partners, and a higher frequency of CMV-specific IgM, suggesting recent CMV infection. By logistic regression, cervical CMV excretion was associated with concomitant gonococcal infection (P = .008) and was less frequent in those using barrier contraception (P = .036). Isolated urinary excretion of CMV was not associated with sexual activity, concomitant cervical infections, or use ofcontraception. Cervical CMV infection is related to sexual activity, acquisition of other STDs, or exogenous reinfection, and urinary CMV is not.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/171.1.33