Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide

A reduction in nitric oxide (NO) synthesis has been suggested to play a role in pregnancy-induced hypertension. We have recently reported that normal pregnancy in the rat is associated with significant increases in whole-body NO production and renal protein expression of neuronal and inducible NO sy...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2001-04, Vol.37 (4), p.1191-1195
Main Authors: ALEXANDER, Barbara T, KASSAB, Salah E, MILLER, M. Todd, ABRAM, Sean R, RECKELHOFF, Jane F, BENNETT, William A, GRANGER, Joey P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - physiology
Diseases of mother, fetus and pregnancy
Estradiol - blood
Female
Glomerular Filtration Rate
Gynecology. Andrology. Obstetrics
Hemodynamics
Kidney - metabolism
Medical sciences
Nitrates - urine
Nitric Oxide - metabolism
Nitrites - urine
Pregnancy
Pregnancy, Animal - physiology
Pregnancy. Fetus. Placenta
Progesterone - blood
Proteinuria - metabolism
Rats
Uterus - blood supply
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Summary:A reduction in nitric oxide (NO) synthesis has been suggested to play a role in pregnancy-induced hypertension. We have recently reported that normal pregnancy in the rat is associated with significant increases in whole-body NO production and renal protein expression of neuronal and inducible NO synthase. The purpose of this study was to determine whether whole-body and renal NO production is reduced in a rat model of pregnancy-induced hypertension produced by chronically reducing uterine perfusion pressure starting at day 14 of gestation. Chronic reductions in uterine perfusion pressure resulted in increases in arterial pressure of 20 to 25 mm Hg, decreases in renal plasma flow (
ISSN:0194-911X
1524-4563
DOI:10.1161/01.HYP.37.4.1191