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The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs
The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxaci...
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| Published in: | Journal of antimicrobial chemotherapy 1986-08, Vol.18 (2), p.251-260 |
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| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c470t-ea82852e5516cee05cc89fd6a81a1505777568beab3a22c99addd2c39559fa0d3 |
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| container_end_page | 260 |
| container_issue | 2 |
| container_start_page | 251 |
| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 18 |
| creator | Saito, Atsushi Koga, Hironobu Shigeno, Hideaki Watanabe, Koichi Mori, Kenji Kohno, Shigeru Shigeno, Yoshiteru Suzuyama, Yoji Yamaguchi, Keizo Hirota, Masaki Hara, Kohel |
| description | The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06mg/1 at 106 cfu inoculum and 0.02 to 0.125 mg/1 at 104 cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order. The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection. |
| doi_str_mv | 10.1093/jac/18.2.251 |
| format | article |
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The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06mg/1 at 106 cfu inoculum and 0.02 to 0.125 mg/1 at 104 cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order. The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/18.2.251</identifier><identifier>PMID: 3759736</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Animals ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Ciprofloxacin - metabolism ; Ciprofloxacin - therapeutic use ; Guinea Pigs ; Legionella - drug effects ; Legionnaires' Disease - drug therapy ; Male ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>Journal of antimicrobial chemotherapy, 1986-08, Vol.18 (2), p.251-260</ispartof><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-ea82852e5516cee05cc89fd6a81a1505777568beab3a22c99addd2c39559fa0d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8783918$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3759736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Atsushi</creatorcontrib><creatorcontrib>Koga, Hironobu</creatorcontrib><creatorcontrib>Shigeno, Hideaki</creatorcontrib><creatorcontrib>Watanabe, Koichi</creatorcontrib><creatorcontrib>Mori, Kenji</creatorcontrib><creatorcontrib>Kohno, Shigeru</creatorcontrib><creatorcontrib>Shigeno, Yoshiteru</creatorcontrib><creatorcontrib>Suzuyama, Yoji</creatorcontrib><creatorcontrib>Yamaguchi, Keizo</creatorcontrib><creatorcontrib>Hirota, Masaki</creatorcontrib><creatorcontrib>Hara, Kohel</creatorcontrib><title>The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs</title><title>Journal of antimicrobial chemotherapy</title><addtitle>J Antimicrob Chemother</addtitle><description>The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06mg/1 at 106 cfu inoculum and 0.02 to 0.125 mg/1 at 104 cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order. The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Ciprofloxacin - metabolism</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Guinea Pigs</subject><subject>Legionella - drug effects</subject><subject>Legionnaires' Disease - drug therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Ciprofloxacin - metabolism</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Guinea Pigs</topic><topic>Legionella - drug effects</topic><topic>Legionnaires' Disease - drug therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. 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| ispartof | Journal of antimicrobial chemotherapy, 1986-08, Vol.18 (2), p.251-260 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025 |
| subjects | Animals Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Ciprofloxacin - metabolism Ciprofloxacin - therapeutic use Guinea Pigs Legionella - drug effects Legionnaires' Disease - drug therapy Male Medical sciences Pharmacology. Drug treatments |
| title | The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs |
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