The antimicrobial activity of ciprofloxacin against Legionella species and the treatment of experimental Legionella pneumonia in guinea pigs

The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxaci...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1986-08, Vol.18 (2), p.251-260
Main Authors: Saito, Atsushi, Koga, Hironobu, Shigeno, Hideaki, Watanabe, Koichi, Mori, Kenji, Kohno, Shigeru, Shigeno, Yoshiteru, Suzuyama, Yoji, Yamaguchi, Keizo, Hirota, Masaki, Hara, Kohel
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Ciprofloxacin - metabolism
Ciprofloxacin - therapeutic use
Guinea Pigs
Legionella - drug effects
Legionnaires' Disease - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
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Summary:The antimicrobial activity of ciprofloxacin was tested against 15 standard reference strains, and 37 clinical and environmental strains of Legionella pneumophila by an agar dilution method, using a new growth medium (B-SYE agar) which we devised. The minimal inhibitory concentrations of ciprofloxacin were found to be inoculum dependent, and ranged from 0.02 to 0.06mg/1 at 106 cfu inoculum and 0.02 to 0.125 mg/1 at 104 cfu inoculum. The most potent antibacterial activity was shown by rifampicin, followed by ofloxacin, ciprofloxacin, enoxacin, norfloxacin, erythromycin and pipemidic acid in that order. The therapeutic efficacy of ciprofloxacin in experimental guinea pig pneumonia due to L. pneumophila was fairly good with a survival rate of 80%. From other data of ours, its effectiveness in experimental pneumonia was equal to or greater than that of erythromycin. Further studies would be appropriate to investigate the possibility of using ciprofloxacin for the treatment of human L. pneumophila infection.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/18.2.251