MR imaging of the wrist in rheumatoid arthritis using gadobenate dimeglumine

To determine the dosage of gadobenate dimeglumine (Gd-BOPTA) necessary for MRI of rheumatoid arthritis of the wrist. Seven wrists inflamed with rheumatoid arthritis were imaged using a dedicated 0.2-T MR unit. Four cumulative dosages of 0.0125, 0.025, 0.05 and 0.1 mmol/kg body weight (BW) Gd-BOPTA w...

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Bibliographic Details
Published in:Skeletal radiology 2001-01, Vol.30 (1), p.15-24
Main Authors: BONEL, H. M, SCHNEIDER, P, SEEMANN, M. D, HUEGLI, R, SRIVASTAV, S, LODEMANN, K. P, REISER, M
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - diagnosis
Biological and medical sciences
Contrast Media - administration & dosage
Diet
Female
gadobenate dimeglumine
Hogs
Humans
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Male
Medical sciences
Meglumine - administration & dosage
Meglumine - analogs & derivatives
Middle Aged
Organometallic Compounds - administration & dosage
Osteoarticular system. Muscles
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Weaning
Wrist
Wrist Joint - pathology
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Summary:To determine the dosage of gadobenate dimeglumine (Gd-BOPTA) necessary for MRI of rheumatoid arthritis of the wrist. Seven wrists inflamed with rheumatoid arthritis were imaged using a dedicated 0.2-T MR unit. Four cumulative dosages of 0.0125, 0.025, 0.05 and 0.1 mmol/kg body weight (BW) Gd-BOPTA were tested. Three-dimensional T1-weighted gradient-recalled echo sequences (GRE; TR: 100 ms, TE: 18 ms, flip angle 90 degrees , 4:55 min) were acquired prior to an intravenous injection and after each additional dosage of Gd-BOPTA. Relative enhancement, signal-difference-to-noise ratios (SDNRs) and the size of the inflamed tissue were quantified. Three radiologists independently evaluated the image quality, the size and the contrast of the enhancing tissue. The readers agreed on a dose of 0.05 mmol/kg BW as satisfactory for the evaluation of the size of the inflammatory tissue and for determination of bone involvement (kappa = 0.9, P < 0.001). Highly inflammatory pannus was depicted with adequate image contrast using 0.025 mmol/kg BW Gd-BOPTA. According to the SDNR and relative enhancement findings, a dose of 0.05 mmol/kg BW suffices for both off-center and centered regions of tissue inflammation (t-test, P < 0.05). Gadolinium-BOPTA is an alternative contrast agent for MRI of rheumatoid disease. This study shows that a dose of 0.05 mmol/kg BW suffices at low field strength.
ISSN:0364-2348
1432-2161
DOI:10.1007/s002560000294