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[PSI+] prion generation in yeast: characterization of the ‘strain’ difference
The yeast cytoplasmically‐inherited nonsense suppressor [PSI+] determinant is presumed to be a manifestation of the aggregated prion‐like state of the Sup35 protein. Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabiliti...
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| Published in: | Yeast (Chichester, England) England), 2001-04, Vol.18 (6), p.489-497 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c3770-156ad3e5519449a2bcf3ce399eb5cc8b34a620a54c15f02d712f5f325026eb0c3 |
| container_end_page | 497 |
| container_issue | 6 |
| container_start_page | 489 |
| container_title | Yeast (Chichester, England) |
| container_volume | 18 |
| creator | Kochneva‐Pervukhova, Natalia V. Chechenova, Maria B. Valouev, Igor A. Kushnirov, Vitaly V. Smirnov, Vladimir N. Ter‐Avanesyan, Michael D. |
| description | The yeast cytoplasmically‐inherited nonsense suppressor [PSI+] determinant is presumed to be a manifestation of the aggregated prion‐like state of the Sup35 protein. Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI+] with different properties depends on the SUP35 allele used to induce their generation. The difference in properties of [PSI+] determinants was preserved after their transmission from one yeast strain to another. This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI+] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants. Copyright © 2001 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/yea.700 |
| format | article |
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Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI+] with different properties depends on the SUP35 allele used to induce their generation. The difference in properties of [PSI+] determinants was preserved after their transmission from one yeast strain to another. This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI+] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants. 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Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI+] with different properties depends on the SUP35 allele used to induce their generation. The difference in properties of [PSI+] determinants was preserved after their transmission from one yeast strain to another. This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI+] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants. Copyright © 2001 John Wiley & Sons, Ltd.</description><subject>Alleles</subject><subject>Blotting, Western</subject><subject>Cell Aggregation - genetics</subject><subject>Cell Cycle</subject><subject>eRF3</subject><subject>Fungal Proteins - biosynthesis</subject><subject>Fungal Proteins - genetics</subject><subject>Gene Expression Regulation, Fungal - genetics</subject><subject>nonsense suppressors</subject><subject>Peptide Termination Factors</subject><subject>Phenotype</subject><subject>Plasmids</subject><subject>prion strains</subject><subject>Prions - genetics</subject><subject>Prions - metabolism</subject><subject>PSI</subject><subject>q@u+ prion protein</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>Species Specificity</subject><subject>Sup35 protein</subject><subject>Sup35p</subject><subject>Suppression, Genetic - genetics</subject><subject>yeast</subject><issn>0749-503X</issn><issn>1097-0061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqFkMFKw0AQQBdRbK3iH0hOeiips7vZbOKtlKqFgooKikjYbGY10iZ1N0XqqZ-hv9cvMSUFT-JpBubxBh4hhxR6FICdLlD1JMAWaVOIpQ8Q0m3SBhnEvgD-0CJ7zr0BUCpYtEtalLIoABBtcvN0fTvqPnszm5eF94IFWlWt17zwaqmrzjz9qqzSFdr8szmVxqte0Vstv1xlVV6slt9elhuDFguN-2THqInDg83skPvz4d3g0h9fXYwG_bGvuZTgUxGqjKMQNA6CWLFUG66RxzGmQuso5YEKGSgRaCoMsExSZoThTAALMQXNO-S48c5s-T5HVyXT3GmcTFSB5dwl9RMWSC7_BamMZEjDqAZPGlDb0jmLJqmrTJVdJBSSdeakLpLUmWvyaKOcp1PMfrlN1xroNsBHPsHFX57kcdhf634ADE-G1g</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Kochneva‐Pervukhova, Natalia V.</creator><creator>Chechenova, Maria B.</creator><creator>Valouev, Igor A.</creator><creator>Kushnirov, Vitaly V.</creator><creator>Smirnov, Vladimir N.</creator><creator>Ter‐Avanesyan, Michael D.</creator><general>John Wiley & Sons, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>200104</creationdate><title>[PSI+] prion generation in yeast: characterization of the ‘strain’ difference</title><author>Kochneva‐Pervukhova, Natalia V. ; Chechenova, Maria B. ; Valouev, Igor A. ; Kushnirov, Vitaly V. ; Smirnov, Vladimir N. ; Ter‐Avanesyan, Michael D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3770-156ad3e5519449a2bcf3ce399eb5cc8b34a620a54c15f02d712f5f325026eb0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Alleles</topic><topic>Blotting, Western</topic><topic>Cell Aggregation - genetics</topic><topic>Cell Cycle</topic><topic>eRF3</topic><topic>Fungal Proteins - biosynthesis</topic><topic>Fungal Proteins - genetics</topic><topic>Gene Expression Regulation, Fungal - genetics</topic><topic>nonsense suppressors</topic><topic>Peptide Termination Factors</topic><topic>Phenotype</topic><topic>Plasmids</topic><topic>prion strains</topic><topic>Prions - genetics</topic><topic>Prions - metabolism</topic><topic>PSI</topic><topic>q@u+ prion protein</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Species Specificity</topic><topic>Sup35 protein</topic><topic>Sup35p</topic><topic>Suppression, Genetic - genetics</topic><topic>yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kochneva‐Pervukhova, Natalia V.</creatorcontrib><creatorcontrib>Chechenova, Maria B.</creatorcontrib><creatorcontrib>Valouev, Igor A.</creatorcontrib><creatorcontrib>Kushnirov, Vitaly V.</creatorcontrib><creatorcontrib>Smirnov, Vladimir N.</creatorcontrib><creatorcontrib>Ter‐Avanesyan, Michael D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Yeast (Chichester, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kochneva‐Pervukhova, Natalia V.</au><au>Chechenova, Maria B.</au><au>Valouev, Igor A.</au><au>Kushnirov, Vitaly V.</au><au>Smirnov, Vladimir N.</au><au>Ter‐Avanesyan, Michael D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>[PSI+] prion generation in yeast: characterization of the ‘strain’ difference</atitle><jtitle>Yeast (Chichester, England)</jtitle><addtitle>Yeast</addtitle><date>2001-04</date><risdate>2001</risdate><volume>18</volume><issue>6</issue><spage>489</spage><epage>497</epage><pages>489-497</pages><issn>0749-503X</issn><eissn>1097-0061</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The yeast cytoplasmically‐inherited nonsense suppressor [PSI+] determinant is presumed to be a manifestation of the aggregated prion‐like state of the Sup35 protein. Overexpression of the Sup35 protein induces generation of [PSI+] determinants with various suppressor efficiency and mitotic stabilities. Here, we demonstrate that the relative frequency of appearance of [PSI+] with different properties depends on the SUP35 allele used to induce their generation. The difference in properties of [PSI+] determinants was preserved after their transmission from one yeast strain to another. This difference correlated with variation in properties of the Sup35 protein. A novel type of prion instability was observed: some [PSI+] with weak suppressor efficiency could convert spontaneously into strong suppressor determinants. Copyright © 2001 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>11284005</pmid><doi>10.1002/yea.700</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Yeast (Chichester, England), 2001-04, Vol.18 (6), p.489-497 |
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| language | eng |
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| source | Wiley |
| subjects | Alleles Blotting, Western Cell Aggregation - genetics Cell Cycle eRF3 Fungal Proteins - biosynthesis Fungal Proteins - genetics Gene Expression Regulation, Fungal - genetics nonsense suppressors Peptide Termination Factors Phenotype Plasmids prion strains Prions - genetics Prions - metabolism PSI q@u+ prion protein Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Species Specificity Sup35 protein Sup35p Suppression, Genetic - genetics yeast |
| title | [PSI+] prion generation in yeast: characterization of the ‘strain’ difference |
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