Effects of dopamine antagonists with different receptor blockade profiles on morphine-induced place preference in male mice

The effects of dopamine (DA) antagonists with different selectivity for the DA receptors (SCH 23390, 0.5, 0.25, 0.125 mg/kg; haloperidol, 0.2, 0.1 mg/kg; raclopride, 1.2, 0.6, 0.3 mg/kg; risperidone, 0.4, 0.2, 0.1 mg/kg; U-99194A maleate, 40, 20 mg/kg; clozapine, 2.5, 1.25, 0.625 mg/kg) on the acqui...

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Bibliographic Details
Published in:Behavioural brain research 2001-06, Vol.121 (1), p.189-197
Main Authors: Manzanedo, Carmen, Aguilar, Marı́a A., Rodrı́guez-Arias, Marta, Miñarro, José
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
Behavioral psychophysiology
Biological and medical sciences
Brain - drug effects
Choice Behavior - drug effects
Clozapine
Conditioning, Classical - drug effects
CPP
Dopamine Antagonists - pharmacology
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Haloperidol
Male
Mice
Morphine
Morphine - pharmacology
Motivation
Neurotransmission and behavior
Orientation - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Raclopride
Receptors, Dopamine - classification
Receptors, Dopamine - drug effects
Risperidone
SCH 23390
U-99194A maleate
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Summary:The effects of dopamine (DA) antagonists with different selectivity for the DA receptors (SCH 23390, 0.5, 0.25, 0.125 mg/kg; haloperidol, 0.2, 0.1 mg/kg; raclopride, 1.2, 0.6, 0.3 mg/kg; risperidone, 0.4, 0.2, 0.1 mg/kg; U-99194A maleate, 40, 20 mg/kg; clozapine, 2.5, 1.25, 0.625 mg/kg) on the acquisition of place conditioning and morphine-induced conditioned place preference (CPP) were explored in male mice. Morphine (40 mg/kg) produced CPP while SCH 23390, haloperidol and clozapine (highest dose) and risperidone (lowest dose) produced conditioned place aversion (CPA). Raclopride and U-99194A maleate did not produce CPP or CPA. Morphine-induced CPP was reversed by the administration of SCH 23390 and risperidone (all doses), haloperidol (highest dose) and raclopride and clozapine (intermediate and lowest doses). U-99194A maleate did not reverse morphine-induced CPP. These results suggest that the conditioned rewarding effects of morphine are mediated by the different subtypes of DA receptors.
ISSN:0166-4328
1872-7549
DOI:10.1016/S0166-4328(01)00164-4