Platelet angiotensin receptors in young and old humans

Platelets from healthy human volunteers were studied for angiotensin II (AII) binding sites. Platelets were isolated from whole blood by differential centrifugation, and binding sites were analyzed by Scatchard plots of radioactive ligand binding data. The number of platelet AII receptor sites was s...

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Bibliographic Details
Published in:Journal of gerontology (Kirkwood) 1986-09, Vol.41 (5), p.574-578
Main Authors: Siebers, M J, Goodfriend, T L
Format: Article
Language:English
Subjects:
Adult
age
Aged
Aging
angiotensin II
Blood Platelets - metabolism
Female
Humans
In Vitro Techniques
Male
man
Middle Aged
platelets
Receptors, Angiotensin - metabolism
Receptors, Cell Surface - metabolism
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Summary:Platelets from healthy human volunteers were studied for angiotensin II (AII) binding sites. Platelets were isolated from whole blood by differential centrifugation, and binding sites were analyzed by Scatchard plots of radioactive ligand binding data. The number of platelet AII receptor sites was significantly higher in human beings of advanced age compared with younger persons. The affinity of receptor sites was not different in young and old participants. The increased number of binding sites bore no relationship to salt intake as documented by history, plasma renin activity, or blood pressure. A significant portion of the increase in platelet AII receptor sites in older adults in this study is related directly to the age of the individuals.
ISSN:0022-1422
2331-3323
DOI:10.1093/geronj/41.5.574